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首页> 外文期刊>The European Journal of Neuroscience >A single dose of lorazepam reduces paired-pulse suppression of median nerve evoked somatosensory evoked potentials
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A single dose of lorazepam reduces paired-pulse suppression of median nerve evoked somatosensory evoked potentials

机译：单剂量劳拉西m可降低中位神经诱发的体感诱发电位的成对脉冲抑制

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Paired-pulse behaviour in the somatosensory cortex is an approach to obtain insights into cortical processing modes and to obtain markers of changes of cortical excitability attributable to learning or pathological states. Numerous studies have demonstrated suppression of the response to the stimulus that follows a first one after a short interval, but the underlying mechanisms remain elusive, although there is agreement that GABAergic mechanisms seem to play a crucial role. We therefore aimed to explore the influence of the GABA(A) agonist lorazepam on paired-pulse somatosensory evoked potentials (SEPs). We recorded and analysed SEPs after paired median nerve stimulation in healthy individuals before and after they had received a single dose of 2.5 mg of lorazepam as compared with a control group receiving placebo. Paired-pulse suppression was expressed as a ratio of the amplitudes of the second and the first peaks. We found that, after lorazepam application, paired-pulse suppression of the cortical N20 component remained unchanged, but suppression of the N20-P25 complex was significantly reduced, indicative of GABAergic involvement in intracortical processing. Our data suggest that lorazepam most likely enhances inhibition within the cortical network of interneurons responsible for creating paired-pulse suppression, leading to reduced inhibitory drive with a subsequently reduced amount of suppression. The results provide further evidence that GABA(A)-mediated mechanisms are involved in the generation of median nerve evoked paired-pulse suppression.
机译：体感皮层中的成对脉冲行为是一种了解皮层加工模式并获得可归因于学习或病理状态的皮层兴奋性变化标记的方法。许多研究表明，在短暂的间隔后，对第一个刺激的反应的抑制作用得到了抑制，但是尽管人们一致认为GABA能机制似乎起着至关重要的作用，但其潜在的机制仍然难以捉摸。因此，我们旨在探讨GABA（A）激动剂劳拉西m对成对脉冲体感诱发电位（SEPs）的影响。我们记录并分析了健康个体在接受单剂​​量2.5 mg劳拉西m之前和之后与接受安慰剂的对照组相比在配对中位神经刺激后的SEP。配对脉冲抑制表示为第二个和第一个峰值的振幅之比。我们发现，劳拉西m应用后，皮层N20组分的成对脉冲抑制作用保持不变，但N20-P25复合物的抑制作用显着降低，表明GABA能参与了皮层内处理。我们的数据表明劳拉西m最有可能增强内部神经元的皮层网络内的抑制作用，该神经元负责产生成对脉冲抑制，从而导致抑制驱动力降低，抑制作用随之降低。结果提供了进一步的证据，表明GABA（A）介导的机制参与正中神经诱发的成对脉冲抑制的产生。

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