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首页> 外文期刊>The European Journal of Neuroscience >Effect of microiontophoretic application of dopamine on subthalamic nucleus neuronal activity in normal rats and in rats with unilateral lesion of the nigrostriatal pathway.
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Effect of microiontophoretic application of dopamine on subthalamic nucleus neuronal activity in normal rats and in rats with unilateral lesion of the nigrostriatal pathway.

机译：微电泳多巴胺对正常大鼠和黑质纹状体途径单侧病变大鼠丘脑膜下核神经元活性的影响。

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The subthalamic nucleus (STN) receives dopamine inputs from the substantia nigra but their implication in the pathophysiology of parkinsonism is still debated. Extracellular microrecordings were used to study the effect of microiontophoretic injection of dopamine and the D1 receptor agonist SKF 38393 on the activity of STN neurons in normal and 6-hydroxydopamine-lesioned rats under urethane anaesthesia. Dopamine and SKF induced an increase in the firing rate of the majority of STN neurons in both normal and 6-OHDA rats. In rats with 6-OHDA lesions, the percentage of firing rate increase did not differ from that of controls. When GABA, glutamate and dopamine were all applied to the same individual STN neurons, GABA induced an inhibitory effect and glutamate and dopamine caused an excitatory effect in both groups. This excitatory response was suppressed by the application of GABA. Systemic administration of apomorphine provoked a decrease in the firing rate of STN neurons in rats with 6-OHDA lesions. These results show that dopamine exerts an excitatory influence on STN neurons, suggesting that the inhibitory effect induced by the systemic injection of apomorphine is due to the GABAergic inputs from the globus pallidus as predicted by the current model of basal ganglia organization. In addition, we show that dopamine, GABA and glutamate can act on the same STN neuron and that GABA can reverse the excitatory effect of dopamine and glutamate, suggesting the predominant influence of GABAergic inputs to the subthalamic nucleus.
机译：丘脑下核（STN）从黑质中接收多巴胺输入，但是它们在帕金森氏症病理生理学中的意义仍在争论中。细胞外微记录用于研究在氨基甲酸乙酯麻醉下正常和6-羟基多巴胺损伤大鼠中多巴胺和D1受体激动剂SKF 38393的微离子电渗疗法对STN神经元活性的影响。在正常和6-OHDA大鼠中，多巴胺和SKF都导致大多数STN神经元的放电速率增加。在患有6-OHDA损伤的大鼠中，射击率增加的百分比与对照组无差异。当将GABA，谷氨酸和多巴胺全部应用于相同的单个STN神经元时，GABA引起抑制作用，而谷氨酸和多巴胺在两组中均引起兴奋作用。通过应用GABA抑制了这种兴奋性反应。阿朴吗啡的全身给药引起6-OHDA损伤的大鼠STN神经元的放电速率降低。这些结果表明，多巴胺对STN神经元具有兴奋性影响，这表明全身注射阿扑吗啡诱导的抑制作用是由于苍白球的GABA能输入所致，正如当前基底神经节组织模型所预测的那样。此外，我们表明，多巴胺，GABA和谷氨酸可以作用于同一STN神经元，并且GABA可以逆转多巴胺和谷氨酸的兴奋作用，表明GABA能量输入对丘脑下核的主要影响。

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