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首页> 外文期刊>The European Journal of Neuroscience >MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli.
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MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli.

机译：大鼠脊髓背角中的MOR-1免疫反应性神经元：含P物质的初级传入神经非突触神经支配以及有毒的热刺激选择性激活的证据。

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摘要

A direct action of mu-opioid agonists on neurons in the spinal dorsal horn is thought to contribute to opiate-induced analgesia. In this study we have investigated neurons that express the mu-opioid receptor MOR-1 in rat spinal cord to provide further evidence about their role in nociceptive processing. MOR-1-immunoreactive cells were largely restricted to lamina II, where they comprised approximately 10% of the neuronal population. The cells received few contacts from nonpeptidergic unmyelinated afferents, but many from substance P-containing afferents. However, electron microscopy revealed that most of these contacts were not associated with synapses. None of the MOR-1 cells in lamina II expressed the neurokinin 1 receptor; however, the mu-selective opioid peptide endomorphin-2 was present in the majority (62-82%) of substance P axons that contacted them. Noxious thermal stimulation of the foot induced c-Fos expression in approximately 15% of MOR-1 cells in the medial third of the ipsilateral dorsal horn at mid-lumbar level. However, following pinching of the foot or intraplantar injection of formalin very few MOR-1 cells expressed c-Fos, and for intraplantar formalin injection this result was not altered significantly by pretreatment with systemic naloxone. Although these findings indicate that at least some of the neurons in lamina II with MOR-1 are activated by noxious thermal stimulation, the results do not support the hypothesis that the cells have a role in transmitting nociceptive information following acute mechanical or chemical noxious stimuli.
机译：mu阿片类激动剂对脊髓背角神经元的直接作用被认为有助于阿片类药物引起的镇痛作用。在这项研究中，我们研究了在大鼠脊髓中表达mu阿片受体MOR-1的神经元，以提供有关其在伤害感受过程中的作用的进一步证据。 MOR-1免疫反应性细胞在很大程度上限于层板II，其中约占神经元人口的10％。这些细胞几乎没有来自非肽能的非髓鞘传入细胞的接触，但是很多来自含P物质的传入细胞。然而，电子显微镜显示，这些接触大多数与突触无关。层板II中的MOR-1细胞均未表达神经激肽1受体。然而，在大多数与之接触的P轴突物质中，μ选择性阿片肽内啡肽2存在（62-82％）。足部的有害热刺激在腰中部水平的同侧背角内侧三分之一中的大约15％的MOR-1细胞中诱导c-Fos表达。然而，在捏脚或福尔马林plant骨内注射后，很少有MOR-1细胞表达c-Fos，而对于福尔马林plant骨内注射，用系统性纳洛酮预处理不会明显改变这一结果。尽管这些发现表明，有害热刺激可激活MOR-1层II中的至少部分神经元，但该结果不支持细胞在急性机械或化学有害刺激后具有传递伤害性信息的作用这一假设。

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