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首页> 外文期刊>The European Journal of Neuroscience >Decreased glucocorticoid receptor mRNA and dysfunction of HPA axis in rats after removal of the cholinergic innervation to hippocampus.
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Decreased glucocorticoid receptor mRNA and dysfunction of HPA axis in rats after removal of the cholinergic innervation to hippocampus.

机译：去除胆碱能神经支配给海马后，大鼠糖皮质激素受体mRNA和HPA轴功能降低。

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摘要

Excess exposure to glucocorticoids can have deleterious effects on physiology and cognition. Glucocorticoids acting via receptors located in hippocampal neurons contribute to negative feedback after stress by terminating the further release of glucocorticoids. The current study investigated the effects of selective immunolesions of septo-hippocampal cholinergic neurons on hippocampal corticosterone receptor mRNA and on hypothalamic-pituitary-adrenal (HPA) activity. As evaluated by in situ hybridization, hippocampal glucocorticoid receptor (GR) mRNA, but not mineralocorticoid receptor (MR) mRNA, was significantly decreased in lesioned rats compared to controls. In a companion study, the peak corticosterone response to one hour of restraint stress did not differ between lesion and control groups but the post-stress decline of corticosterone was more protracted in the lesioned rats. These findings are discussed in terms of their possible relevance to ageing as age-related degeneration of the basal forebrain cholinergic system may contribute to the commonly observed dysfunction of the HPA axis in older animals.
机译：过量暴露于糖皮质激素可能会对生理和认知产生有害影响。通过位于海马神经元中的受体起作用的糖皮质激素通过终止糖皮质激素的进一步释放而在应激后导致负反馈。当前的研究调查了隔垫海马胆碱能神经元的选择性免疫损伤对海马皮质酮受体mRNA和下丘脑-垂体-肾上腺（HPA）活性的影响。通过原位杂交评估，与对照组相比，病变大鼠的海马糖皮质激素受体（GR）mRNA显着降低，而盐皮质激素受体（MR）mRNA则没有明显降低。在一项伴随研究中，病变组和对照组之间，皮质酮对一小时约束性应激的峰值反应没有差异，但病变大鼠中皮质酮的应激后下降更为持久。对这些发现与它们可能与衰老的关系进行了讨论，因为与年龄相关的基础前脑胆碱能系统退化可能会导致老年动物中常见的HPA轴功能障碍。

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