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首页> 外文期刊>The European Journal of Neuroscience >Increased BDNF and trk-B mRNA expression in cortical and limbic regions following formation of a social recognition memory.
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Increased BDNF and trk-B mRNA expression in cortical and limbic regions following formation of a social recognition memory.

机译：社交识别记忆形成后，BDNF和trk-B mRNA在皮质和边缘区的表达增加。

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摘要

Brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine receptor kinase (trk-B), play important roles in neural plasticity, long-term potentiation and memory formation. Sheep form a selective recognition memory for their lambs within 2 h of birth. Initially, this memory is exclusively based on olfactory cues; however, as it consolidates over a 12-h recognition period it extends to incorporate visual cues. We investigated whether changes in BDNF and trk-B mRNA expression occurred in both olfactory and visual processing systems at 4.5 h postpartum, 2-3 h after the behavioural manifestations of an olfactory recognition memory were found. Animals that formed a recognition memory showed increased BDNF mRNA expression in the inferior part of the temporal cortex, subfield CA1 of the hippocampus, the diagonal band, basolateral amygdala and the anterior cingulate, medial frontal, entorhinal and pyriform cortices. No increases were observed in either the olfactory bulbs or the dentate gyrus. Expression of trk-B mRNA was significantly increased only in the medial temporal, entorhinal and pyriform cortices. These findings demonstrate that by 2-3 h following the initial formation of olfactory recognition memory there are BDNF/trk-B-mediated plasticity changes in brain areas involved in the consolidation of olfactory memory (the pyriform and entorhinal cortices). However, similar changes also occur in areas of the brain involved in visual memory, face and object recognition (the temporal cortex, entorhinal cortex, hippocampal subfield CA1 and basolateral amygdala), and in areas of the brain with integrative and attentional functions (the medial frontal and anterior cingulate cortices and diagonal band). This suggests that reorganization of neural circuits underlying the visual recognition of lambs or the integration of olfactory/visual information is occurring even at this time even though accurate behavioural recognition at this stage can only be made using olfactory cues.
机译：脑源性神经营养因子（BDNF）及其受体酪氨酸受体激酶（trk-B）在神经可塑性，长期增强和记忆形成中起重要作用。绵羊在出生后2小时内会对其小羊形成选择性识别记忆。最初，此记忆仅基于嗅觉提示;但是，由于在12小时的识别时间内进行了合并，因此扩展到包含视觉提示。我们调查了嗅觉识别记忆的行为表现后2-3小时，在产后4.5小时，嗅觉和视觉处理系统中BDNF和trk-B mRNA表达的变化是否发生。形成识别记忆的动物在颞皮质下部，海马CA1区，对角带，基底外侧杏仁核和前扣带状，内侧额叶，内啡肽和吡喃状皮质中显示BDNF mRNA表达增加。在嗅球或齿状回中均未观察到增加。 trk-B mRNA的表达仅在颞内侧，内嗅和梨状皮质中显着增加。这些发现表明，在嗅觉识别记忆最初形成后的2-3小时内，BDNF / trk-B介导的可塑性变化在参与嗅觉记忆巩固的大脑区域（梨形和内嗅皮质）中。但是，在涉及视觉记忆，面部和物体识别的大脑区域（颞皮质，内嗅皮质，海马亚区CA1和基底外侧杏仁核）以及具有整合和注意力功能的大脑区域（内侧额叶和前扣带回皮质和对角带）。这表明，即使在这个时候，即使只能使用嗅觉线索来进行准确的行为识别，但即使在这个时候，仍会发生对羔羊的视觉识别或嗅觉/视觉信息整合的神经回路的重组。

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