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首页> 外文期刊>The European Journal of Neuroscience >Novel expression of AMPA-receptor subunit GluR1 on mossy cells and CA3 pyramidal neurons in the human epileptogenic hippocampus.
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Novel expression of AMPA-receptor subunit GluR1 on mossy cells and CA3 pyramidal neurons in the human epileptogenic hippocampus.

机译：AMPA受体亚基GluR1在人癫痫海马体的苔藓细胞和CA3锥体神经元上的新表达。

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Previous immunocytochemical investigations performed in our laboratory on the human hippocampus surgically resected for the treatment of mesial temporal lobe epilepsy (MTLE) have demonstrated an increased expression of the AMPA-receptor subunit GluR1 on neurons in the hilus and area CA3. Light microscopically, many of these neurons exhibited peculiar filamentous extensions and grape-like excrescences that protruded from their somata and proximal dendrites, suggesting that these neurons may be mossy cells and CA3 pyramidal neurons, respectively. The present electron microscopic study was carried out to further characterize these cells. The filamentous extensions were identified as dendrites from which spines often protruded, and the grape-like excrescences represented clusters of closely associated dendrites and spines. A variety of synapses were formed by the GluR1-positive profiles. These arrangements ranged from simple contacts between a single unlabelled axon terminal and a single labelled postsynaptic element, to complex contacts involving multiple unlabelled axon terminals and labelled postsynaptic elements. Many of the axon terminals involved in these arrangements were mossy fibre boutons. Thus, a large proportion of the GluR1-positive neurons were identified as hilar mossy cells and CA3 pyramidal neurons, cells hitherto thought to be absent or greatly reduced in the MTLE hippocampus. Taken together, these data suggest the presence of a highly efficient excitatory circuit involving AMPA receptors, mossy cells and CA3 pyramidal neurons in the sclerotic hippocampus. Such a circuit could be critically involved in the genesis and maintenance of temporal lobe epilepsy.
机译：先前在我们实验室中对手术切除的人类颞叶癫痫（MTLE）进行手术切除的人类海马进行的免疫细胞化学研究表明，AMPA受体亚基GluR1在希拉和CA3区神经元上的表达增加。用显微镜观察，这些神经元中有许多表现出从它们的躯体和近端树突突出的特殊的丝状延伸和葡萄状的异常，表明这些神经元可能分别是苔藓细胞和CA3锥体神经元。进行本电子显微镜研究以进一步表征这些细胞。丝状延伸被确定为通常从其突出的树突，并且葡萄状的茂盛代表紧密相关的树突和刺的簇。 GluR1阳性谱形成了各种突触。这些安排的范围从单个未标记的轴突末端和单个标记的突触后元件之间的简单接触到涉及多个未标记的轴突末端和标记的突触后元件的复杂接触。这些布置中涉及的许多轴突末端是长满苔藓的纤维钮扣。因此，大部分的GluR1阳性神经元被鉴定为肺门苔藓细胞和CA3锥体神经元，迄今为止认为这些细胞在MTLE海马中不存在或大大减少。综上所述，这些数据表明，硬化性海马中存在涉及AMPA受体，苔藓细胞和CA3锥体神经元的高效兴奋性回路。这种电路可能与颞叶癫痫的发生和维持密切相关。

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