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首页> 外文期刊>The European Journal of Neuroscience >Cerebellar brain inhibition in the target and surround muscles during voluntary tonic activation
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Cerebellar brain inhibition in the target and surround muscles during voluntary tonic activation

机译：自愿进补激活期间小脑对目标和周围肌肉的抑制作用

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Motor surround inhibition is the neural mechanism that selectively favours the contraction of target muscles and inhibits nearby muscles to prevent unwanted movements. This inhibition was previously reported at the onset of a movement, but not during a tonic contraction. Cerebellar brain inhibition (CBI) is reduced in active muscles during tonic activation; however, it has not been studied in the surround muscles. CBI was evaluated in the first dorsal interosseus (FDI) muscle as the target muscle, and the abductor digiti minimi, flexor carpi radialis and extensor carpi radialis muscles as surround muscles, during rest and tonic activation of the FDI muscle in 21 subjects. Cerebellar stimulation was performed under magnetic resonance imaging-guided neuronavigation targeting lobule VIII of the cerebellar hemisphere. Stimulus intensities for cerebellar stimulation were based on the resting motor cortex threshold (RMT) and adjusted for the depth difference between the cerebellar and motor cortices. We used 90-120% of the adjusted RMT as the conditioning stimulus intensity during rest. The intensity that generated the best CBI at rest in the FDI muscle was selected for use during tonic activation. During selective tonic activation of the FDI muscle, CBI was significantly reduced only for the FDI muscle, and not for the surround muscles. Unconditioned motor evoked potential sizes were increased in all muscles during FDI muscle tonic activation as compared with rest, despite background electromyography activity increasing only for the FDI muscle. Our study suggests that the cerebellum may play an important role in selective tonic finger movement by reducing its inhibition in the motor cortex only for the relevant agonist muscle.
机译：运动包围抑制是一种神经机制，可选择性地促进目标肌肉的收缩并抑制附近的肌肉以防止不必要的运动。先前在运动开始时报道了这种抑制作用，但在强直性收缩期间没有报道。在补剂激活过程中，活跃肌肉中的小脑脑抑制（CBI）减少;但是，尚未在周围的肌肉中进行研究。在21名受试者的休息和强直激活过程中，以第一背骨（FDI）肌肉为目标肌肉，以外展指肌，mini屈腕pi肌和ex伸腕肌为环绕肌评估了CBI。小脑刺激是在磁共振成像引导的神经导航下靶向小脑半球小叶VIII进行的。小脑刺激的刺激强度基于静止的运动皮层阈值（RMT），并针对小脑和运动皮层之间的深度差进行了调整。我们使用调整后RMT的90-120％作为休息期间的调节刺激强度。选择在FDI肌肉中静止时产生最佳CBI的强度，以在补品激活过程中使用。在FDI肌肉的选择性补剂激活过程中，仅FDI肌肉的CBI显着降低，而周围肌肉则没有。与静态相比，FDI肌肉强直激活过程中所有肌肉的无条件运动诱发电位大小均增加，尽管背景肌电图活动仅针对FDI肌肉增加。我们的研究表明，小脑可能通过减少仅对相关激动剂肌肉的运动皮层抑制而在选择性补剂手指运动中发挥重要作用。

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