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首页> 外文期刊>The European Journal of Neuroscience >Timecourse of object-related neural activity in the primate prefrontal cortex during a short-term memory task.
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Timecourse of object-related neural activity in the primate prefrontal cortex during a short-term memory task.

机译：在短期记忆任务中，灵长类前额叶皮层中与对象相关的神经活动的时程。

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摘要

We studied the timecourse of neural activity in the primate (Macacca mulatta) prefrontal (PF) cortex during an object delayed-matching-to-sample (DMS) task. To assess the effects of experience on this timecourse, we conducted the task using both novel and highly familiar objects. In addition, noise patterns containing no task-relevant information were used as samples on some trials. Comparison of average PF ensemble activity relative to baseline activity generated by objects and noise patterns revealed three distinct activity periods. (i) Sample onset elicited a transient sensory visual response. In this sensory period, novel objects elicited stronger average ensemble activity than both familiar objects and noise patterns. (ii) An intermediate period of elevated activity followed, which began before sample offset, and continued well into the delay period. In the intermediate period, activity was elevated for noise patterns and novel objects, but near baseline for familiar objects. (iii) Finally, after average ensemble activity reached baseline activity at the end of the intermediate period, a reactivation period occurred late in the delay. Experience had little effect during reactivation, where activity was elevated for both novel and familiar objects compared to noise patterns. We show that the ensemble average resembles the activity timecourse of many single prefrontal neurons. These results suggest that PF delay activity does not merely maintain recent sensory input, but is subject to more complex experience-dependent dynamics. This has implications for how delay activity is generated and maintained.
机译：我们研究了对象延迟匹配到样本（DMS）任务期间，灵长类（Macacca mulatta）前额叶（PF）皮质中神经活动的时程。为了评估经验对这一时间过程的影响，我们使用新颖且高度熟悉的物体进行了这项任务。另外，在某些试验中，使用不包含任务相关信息的噪声模式作为样本。比较平均PF合奏活动相对于对象和噪声模式生成的基线活动，发现了三个不同的活动周期。 （i）样品发作引起短暂的感觉视觉反应。在这个感官时期，与熟悉的物体和噪声模式相比，新颖的物体引起了更强的平均合奏活动。 （ii）随后是活性升高的中间时期，该时期开始于样品补偿之前，并一直持续到延迟时期。在中期，噪声模式和新颖物体的活动性增加，但熟悉物体的活动性接近基线。 （iii）最后，在中间阶段结束时平均合奏活动达到基准活动之后，重新激活阶段发生在延迟的后期。经验在重新激活期间几乎没有影响，与噪声模式相比，新奇和熟悉的对象的活动都增加了。我们表明，合奏平均类似于许多单个前额叶神经元的活动时程。这些结果表明，PF延迟活动不仅维持最近的感觉输入，而且还受到更复杂的依赖于经验的动力学的影响。这对延迟活动的产生和维持方式有影响。

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