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首页> 外文期刊>The European Journal of Neuroscience >Neuronal responses of the rat amygdala during extinction and reassociation learning in elementary and configural associative tasks.
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Neuronal responses of the rat amygdala during extinction and reassociation learning in elementary and configural associative tasks.

机译：在基本和构型关联任务中，在灭绝和重新关联学习过程中大鼠杏仁核的神经元反应。

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To investigate functional heterogeneity within the amygdala in appetitive conditioned instrumental behaviours, neuronal activity was recorded from the amygdala of behaving rats during learning and discrimination of conditioned sensory stimuli associated with or without reinforcement [sucrose solution, intracranial self-stimulation (ICSS)]. Sensory stimuli included auditory (tone), visual (light) and configural (simultaneous presentation of tone and light) stimuli. The rat was trained to lick a spout protruded close to its mouth just after a conditioned sensory stimulus to obtain a reward. Of the 609 neurons recorded from the amygdala and amygdalostriatal transition area, 154 responded to one or more sensory stimuli. The 62 amygdalar neurons responded strongly to certain conditioned sensory stimuli associated with rewards. Of these 62 neurons, 45 were tested with the extinction trials. Responses of 31 neurons to conditioned stimuli were finally extinguished, and those of the remaining 14 were not extinguished. Furthermore, responses of 26 of these 31 neurons resumed in the relearning trials (plastic neurons), suggesting that these sensory responses were associative rather than just responses to physical properties of the stimuli. These plastic neurons were located mainly in the basolateral nucleus of the amygdala, and responses of the plastic neurons were correlated with behavioural responses. These results suggest that the basolateral nucleus is crucial in associative learning between sensory information and affective significance for behavioural outputs in appetitive conditioned instrumental behaviours.
机译：为了研究在有条件的有条件的仪器行为中杏仁核内的功能异质性，在学习和辨别有或没有强化[蔗糖溶液，颅内自我刺激（ICSS）]的有条件的感觉刺激期间，从行为大鼠的杏仁核记录神经元活性。感觉刺激包括听觉（音调），视觉（光）和形态（音调和光的同时呈现）刺激。训练大鼠在有条件的感觉刺激后舔嘴突出到嘴附近，以得到奖励。从杏仁核和杏仁扁桃体过渡区记录的609个神经元中，有154个对一种或多种感觉刺激作出了反应。 62个杏仁核神经元对与奖励相关的某些条件性感觉刺激强烈反应。在这62个神经元中，有45个经过了灭绝试验测试。最终消除了31个神经元对条件刺激的反应，而其余14个神经元的反应没有被消除。此外，在相关的研究中（再生神经元）恢复了这31个神经元中的26个的反应，这表明这些感觉反应是联想的，而不仅仅是对刺激物性的反应。这些可塑性神经元主要位于杏仁核的基底外侧核中，并且可塑性神经元的反应与行为反应相关。这些结果表明，基底外侧核对于在有条件的有条件的工具行为中的感觉信息和行为输出的情感意义之间的关联学习至关重要。

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