• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Effects of transgenic overproduction of CRH on anxiety-like behaviour.
【24h】

Effects of transgenic overproduction of CRH on anxiety-like behaviour.

机译：CRH转基因过量生产对焦虑样行为的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Central administration of corticotropin-releasing hormone increases anxiety-like behaviour and arousal in rodents, and increased anxiety-like behaviour has been shown in mice overproducing corticotropin-releasing hormone on an elevated plus maze and in a dark-light emergence task. However, evidence is accumulating that measures obtained from different anxiety tasks may reflect different aspects of anxiety-like behaviour in animals. We therefore tested mice overproducing corticotropin-releasing hormone in a battery of paradigms, studying spontaneous behaviour after a mild stressor, tasks of innate anxiety-like behaviour (light-dark box), lick suppression (Vogel conflict), conditioned fear, and forced swimming. Exploratory behaviour was studied in a 16-hole board task. Furthermore, pain threshold, water intake, locomotor activity and sensorimotor learning/co-ordination were tested to control for confounding factors. In line with previous findings, increased anxiety-like behaviour of transgenic mice was observed in the light-dark box paradigm. However, no differences were seen in the conflict paradigm. Conditioned fear was decreased 1 h but not 24 h after conditioning in transgenic mice, and immobility was increased in forced swimming in corticotropin-releasing hormone overexpressors. Locomotor activity in a novel open field and on the hole board was reduced in transgenics. Exploratory behaviour (hole pokes) was reduced during initial exploration of an unfamiliar hole board. Moreover, sensorimotor performance on a rotorod was impaired, and water intake was reduced in corticotropin-releasing hormone overproducing mice, while no changes were seen in nociception. No differences in locomotor activity were seen in a second group of mice, tested in a familiar open field. When these animals were challenged with diazepam, transgenic mice were less susceptible to the sedative effects of the drug on locomotor activity. These data suggest that corticotropin-releasing hormone overproduction leads to specific effects in a subset of anxiety paradigms, and that these transgenic mice suffer from a motor deficit in addition to altered anxiety-like behaviour/arousal.
机译：集中施用促肾上腺皮质激素释放激素可增加啮齿类动物的焦虑样行为和唤醒，并且在高迷宫和暗光出现任务中，过量生产促肾上腺皮质激素释放激素的小鼠表现出焦虑样行为增加。但是，越来越多的证据表明，从不同的焦虑任务中获得的测量结果可能反映出动物中焦虑样行为的不同方面。因此，我们测试了一组范例中过量产生促肾上腺皮质激素释放激素的小鼠，研究了轻度应激源后的自发行为，先天性焦虑样行为（浅色暗框），舔suppression（Vogel冲突），有条件的恐惧和强迫游泳。在16孔板任务中研究了探索行为。此外，还测试了疼痛阈值，饮水量，运动能力和感觉运动学习/协调能力，以控制混杂因素。与以前的发现一致，在明暗盒范例中观察到转基因小鼠的焦虑样行为增加。但是，在冲突范例中没有发现差异。转基因小鼠适应后1小时，条件恐惧有所减轻，但24小时没有降低，在促肾上腺皮质激素释放激素过表达的强迫游泳中，固定性恐惧增加。在转基因植物中，在新的开放视野和孔板上的运动活性降低。在不熟悉的孔板的初始探索过程中，探索行为（洞戳）减少了。此外，在释放促肾上腺皮质激素的激素过多的小鼠中，旋翼机上的感觉运动性能受损，并且饮水量减少，而伤害感受没有变化。在熟悉的旷野中测试的第二组小鼠中未观察到运动能力的差异。当这些动物用地西epa攻击时，转基因小鼠对药物对运动活性的镇静作用较不敏感。这些数据表明，促肾上腺皮质激素释放激素的过度生产会导致一部分焦虑范式产生特定作用，这些转基因小鼠除了患有类似焦虑症的行为/行为外，还患有运动障碍。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号