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首页> 外文期刊>The European Journal of Neuroscience >Effects of nursing mothers on rPer1 and rPer2 circadian expressions in the neonatal rat suprachiasmatic nuclei vary with developmental stage.
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Effects of nursing mothers on rPer1 and rPer2 circadian expressions in the neonatal rat suprachiasmatic nuclei vary with developmental stage.

机译：哺乳期母亲对新生大鼠视交叉上核rPer1和rPer2昼夜节律表达的影响随发育阶段而变化。

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摘要

The ability of nursing mothers to entrain the circadian pacemaker of rat pups was examined by measuring the rat Per1 (rPer1) and rPer2 expression levels in the suprachiasmatic nuclei (SCN). Newborn rats from mothers under a light-dark cycle (LD) were blinded immediately after birth and reared by foster mothers under either LD (LD blind pups) or reversed light-dark cycle (DL; DL blind pups). At postnatal day (P)6, small but significant phase differences were observed in the circadian gene expression rhythms of the SCN not only between the blind and sighted pups, but also between the two groups of blind pups, indicating the involvement of both free-running and maternal influence in phase-resetting the circadian rhythms of blind pups. However, from P6 to P13 the circadian rhythms of both LD and DL blind pups showed phase delays of similar extent, which suggests that the influence of nursing mothers was lost. From P13 to P20 (the day of weaning), the rPer1 and rPer2 rhythms phase-shifted in a different manner, the rPer2 rhythm being related more closely to the behavioural rhythm than was the rPer1. This finding suggests a differential influence of mothers on the rPer1 and rPer2 rhythms in the third week of life. It is concluded that the ability of nursing mothers to entrain pup circadian oscillation depends on the developmental stage.
机译：通过测量大鼠视交叉上核（SCN）中的Per1（rPer1）和rPer2表达水平，检查了哺乳期母亲带动大鼠小动物昼夜节律起搏器的能力。产后立即将来自明-暗周期（LD）下母亲的新生大鼠致盲，并由寄养母亲在LD（LD盲孔幼崽）或反向明-暗周期（DL; DL盲孔幼崽）下抚养。在出生后第6天，SCN的昼夜节律基因表达节律中观察到微小但显着的相差，不仅在有眼和有眼的幼崽之间，而且在两组有眼的幼崽之间，这表明自由-奔跑和母体影响来重置幼仔的昼夜节律。然而，从P6到P13，LD和DL盲仔的昼夜节律都显示出相似程度的相位延迟，这表明失去了哺乳母亲的影响。从P13到P20（断奶的那天），rPer1和rPer2的节奏以不同的方式相移，与rPer1相比，rPer2的节奏与行为节奏更紧密相关。这一发现表明，母亲在出生后第三周对rPer1和rPer2节律的影响不同。结论是，哺乳母亲带动幼犬昼夜节律振荡的能力取决于发育阶段。

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