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首页> 外文期刊>The European Journal of Neuroscience >Differences in GABAergic transmission between two inputs into the perirhinal cortex.
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Differences in GABAergic transmission between two inputs into the perirhinal cortex.

机译：两个输入到周围皮层的GABA能传递之间的差异。

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摘要

We have investigated properties of GABAergic synaptic transmission in perirhinal cortex evoked by stimulation of temporal and entorhinal cortex sides. GABAA IPSCs were isolated by blockade of glutamatergic transmission in slices of adult perirhinal cortex; IPSC decay was best fitted with two exponentials. Interestingly, temporal IPSCs had a larger slow component of decay (P < 0.05) compared to entorhinal IPSCs. Depression of IPSCs by the GABAB receptor agonist baclofen was greater (P < 0.05) in the temporal input (79 +/- 4% depression) than the entorhinal input (65 +/- 3% depression). Furthermore, baclofen abolished the slow component of IPSC decay in both inputs. Activity-dependent depression of IPSCs at 5 Hz was greater (P < 0.05) in the temporal input [paired pulse ratio (PPR) 0.5 +/- 0.04] compared to that in the entorhinal input (PPR 0.67 +/- 0.02, n = 10). The differences in paired pulse depression between the inputs were removed by the GABAB receptor antagonist CGP55845A. This study demonstrates several differences in GABA transmission between temporal and entorhinal inputs including the differential activation of presynaptic GABAB receptors and differential regulation of inhibitory synaptic transmission. These properties may be important in the control of neuronal activity within perirhinal cortex.
机译：我们已经研究了由颞叶和内嗅皮层两侧的刺激引起的围皮皮质中GABA能突触传递的特性。 GABAA IPSCs是通过阻断成人成年周围皮层中的谷氨酸能传递而分离的。 IPSC衰减最好与两个指数拟合。有趣的是，与内嗅IPSC相比，颞IPSC的衰减慢成分更大（P <0.05）。 GABAB受体激动剂巴氯芬对IPSC的抑制作用在颞部输入（79 +/- 4％抑制）比内嗅输入（65 +/- 3％抑制）更大（P <0.05）。此外，巴氯芬消除了两个输入中IPSC衰减的缓慢成分。与内嗅神经输入（PPR 0.67 +/- 0.02）相比，暂时输入[成对脉冲比率（PPR）为0.5 +/- 0.04]时，IPSC在5 Hz时的活动依赖性抑制更大（P <0.05）。 10）。输入之间配对脉冲抑制的差异已由GABAB受体拮抗剂CGP55845A消除。这项研究证明了时空和内嗅输入之间GABA传递的一些差异，包括突触前GABA B受体的差异激活和抑制性突触传递的差异调节。这些特性可能在控制周围神经皮层神经元活动中很重要。

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