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首页> 外文期刊>The European Journal of Neuroscience >Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation
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Asymmetric time-dependent activation of right central amygdala neurones in rats with peripheral neuropathy and pregabalin modulation

机译：周围神经病和普瑞巴林调节大鼠右中央杏仁核神经元的不对称时间依赖性激活

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Neuropathic pain (NP) often presents with comorbidities, including depression and anxiety. The amygdala is involved in the processing of mood disorders, fear, and the emotional-affective components of pain. Hemispheric lateralization of pain processing in the amygdala has recently been brought to light because, independently of the side of the peripheral injury, the right central nucleus of the amygdala (CeA) showed higher neuronal activity than the left in models of inflammatory pain. Although the CeA has been called the 'nociceptive amygdala', because of its high content of nociceptive neurones, little is known about changes in its neuronal function in vivo, under NP conditions. Herein, we quantified CeA spontaneous and evoked activity in rats subjected to spinal nerve ligation (SNL), under isoflurane anaesthesia, following application of mechanical and thermal stimuli to widespread body areas. We found that spontaneous and stimulus-evoked neuronal activity was higher in the left CeA at 2 and 6days after SNL induction and declined afterwards, whereas activity in the right CeA became dominant at 14days after surgery, independently of the side of surgery. We also observed that systemic injection of pregabalin, which is widely used in patients with NP, reduced CeA spontaneous and stimulus-evoked neuronal activity. Overall, we observed that peripheral nerve injury produced asymmetric plasticity in ongoing and evoked activity in the left and right CeA. Remarkably, at 14days after SNL induction, enhanced evoked activity in the right CeA persisted compared to short-term increases in activity in the left CeA. The plasticity found in ongoing and evoked activity was inhibited by pregabalin.
机译：神经性疼痛（NP）通常伴有合并症，包括抑郁症和焦虑症。杏仁核参与情绪障碍，恐惧和疼痛的情感影响成分的处理。杏仁核疼痛处理的半球偏侧化最近已暴露出来，因为在炎性疼痛模型中，杏仁核的右中枢核（CeA）独立于外周损伤的一侧，其神经元活性高于左侧。尽管CeA被称为“伤害感受性杏仁核”，但由于其伤害感受性神经元的含量较高，因此在NP条件下其体内神经元功能的变化知之甚少。本文中，我们在异氟烷麻醉下，对广泛的身体区域应用机械和热刺激后，对接受脊髓神经结扎（SNL）的大鼠中CeA的自发和诱发的活动进行了定量。我们发现，在SNL诱导后第2天和第6天，左侧CeA的自发性和刺激诱发的神经元活动较高，此后下降，而在右侧CeA的活动在术后14天成为主导，独立于手术侧。我们还观察到广泛用于NP患者的普瑞巴林全身注射降低了CeA的自发性和刺激诱发的神经元活性。总的来说，我们观察到周围神经损伤在左侧和右侧CeA的持续活动和诱发活动中产生不对称可塑性。值得注意的是，与左CeA活动的短期增加相比，SNL诱导后14天，右CeA的诱发活动持续增强。在进行中和诱发的活动中发现的可塑性受到普瑞巴林的抑制。

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