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首页> 外文期刊>The European Journal of Neuroscience >Estradiol acts during a post-pubertal sensitive period to shorten free-running circadian period in male Octodon degus
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Estradiol acts during a post-pubertal sensitive period to shorten free-running circadian period in male Octodon degus

机译：雌二醇在青春期后敏感期起作用，以缩短雄性Octodon degus的自律昼夜节律

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摘要

The free-running circadian period is approximately 30min shorter in adult male than in adult female Octodon degus. The sex difference emerges after puberty, resulting from a shortened free-running circadian period in males. Castration before puberty prevents the emergence of the sex difference, but it is not a function of circulating gonadal hormones as such, because castration later in life does not affect free-running circadian period. The aim of this study was to determine whether or not the shortening of the free-running circadian period in male degus results from exposure to gonadal hormones after puberty. We hypothesized that masculinization of the circadian period results from an organizational effect of androgen exposure during a post-pubertal sensitive period. Male degus were castrated before puberty and implanted with capsules filled with dihydrotestosterone (DHT), 17β-estradiol (E2) or empty capsules at one of three ages: peri-puberty (2-7months), post-puberty (7-12months), or adulthood (14-19months). Long-term exposure to DHT or E2 did not result in a shortened free-running circadian period when administered at 2-7 or 14-19months of age. However, E2 treatment from 7 to 12months of age decreased the free-running circadian period in castrated males. This result was replicated in a subsequent experiment in which E2 treatment was limited to 8-12months of age. E2 treatment at 7-12months of age had no effect on the free-running circadian period in ovariectomized females. Thus, there appears to be a post-pubertal sensitive period for sexual differentiation of the circadian system of degus, during which E2 exposure decreases the free-running circadian period in males. These data demonstrate that gonadal hormones can act during adolescent development to permanently alter the circadian system.
机译：成年男性的自控昼夜节律约短于成年女性八达通天体约30分钟。男性青春期后的自律昼夜节律缩短，导致性别差异在青春期后出现。青春期前的割可防止性别差异的出现，但这不是循环性腺激素的功能，因为生命后期的cast割不会影响自律性昼夜节律。这项研究的目的是确定男性天体的自律性昼夜节律周期的缩短是否是由于青春期后接触性腺激素引起的。我们假设昼夜节律期的男性化是由青春期后敏感期雄激素暴露的组织效应引起的。雄性天体在青春期之前被cast割，并在以下三个年龄之一植入装有二氢睾丸激素（DHT），17β-雌二醇（E2）或空胶囊的胶囊：青春期前后（2-7个月），青春期后（7-12个月），或成年（14-19个月）。当在2-7个月或14-19个月大时服用，长期暴露于DHT或E2并不会缩短自律性昼夜节律。然而，从7到12个月大的E2治疗降低了cast割的男性的自律昼夜节律时间。该结果在随后的实验中得到了重复，在该实验中，E2治疗被限制在8-12个月大。切除卵巢的女性在7-12个月大时进行E2治疗对自律昼夜节律没有影响。因此，似乎存在青春期后天体昼夜节律系统的性别分化敏感期，在此期间，E2暴露会减少男性的自律性昼夜节律期。这些数据表明，性腺激素可以在青春期发育中起作用，从而永久改变昼夜节律系统。

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