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首页> 外文期刊>The European Journal of Neuroscience >Perceived helplessness is associated with individual differences in the central motor output system
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Perceived helplessness is associated with individual differences in the central motor output system

机译：感知到的无助与中央电机输出系统中的个体差异相关

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摘要

Learned helplessness is a maladaptive response to uncontrollable stress characterized by impaired motor escape responses, reduced motivation and learning deficits. There are important individual differences in the likelihood of becoming helpless following exposure to uncontrollable stress but little is known about the neural mechanisms underlying these individual differences. Here we used structural MRI to measure gray and white matter in individuals with chronic pain, a population at high risk for helplessness due to prolonged exposure to a poorly controlled stressor (pain). Given that self-reported helplessness is predictive of treatment outcomes in chronic pain, understanding such differences might provide valuable clinical insight. We found that the magnitude of self-reported helplessness correlated with cortical thickness in the supplementary motor area (SMA) and midcingulate cortex, regions implicated in cognitive aspects of motor behavior. We then examined the white matter connectivity of these regions and found that fractional anisotropy of connected white matter tracts along the corticospinal tract was associated with helplessness and mediated the relationship between SMA cortical thickness and helplessness. These data provide novel evidence that links individual differences in the motor output pathway with perceived helplessness over a chronic and poorly controlled stressor.
机译：习得性无助是对无法控制的压力的适应不良反应，其特征是运动逃逸反应受损，动机减少和学习不足。在暴露于无法控制的压力后变得无助的可能性存在重要的个体差异，但对这些个体差异背后的神经机制了解甚少。在这里，我们使用结构性MRI来测量患有慢性疼痛的人的灰色和白色物质，这些人由于长期暴露于控制不良的压力源（疼痛）中而无助的风险很高。鉴于自我报告的无助感可以预测慢性疼痛的治疗结果，因此了解这种差异可能会提供有价值的临床见解。我们发现自我报告的无助的程度与辅助运动区（SMA）和中扣带回皮层的皮质厚度相关，这些区域牵涉到运动行为的认知方面。然后，我们检查了这些区域的白质连通性，发现沿皮质脊髓束连接的白质束的分数各向异性与无助感有关，并介导了SMA皮质厚度与无助感之间的关系。这些数据提供了新颖的证据，将运动输出路径中的个体差异与在长期且控制不佳的压力源上的无助感联系起来。

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