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首页> 外文期刊>The European Journal of Neuroscience >Cortical interneurons, immune factors and oxidative stress as early targets for schizophrenia
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Cortical interneurons, immune factors and oxidative stress as early targets for schizophrenia

机译：皮质中间神经元，免疫因子和氧化应激为精神分裂症的早期靶标

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摘要

Schizophrenia is a common disorder in which strong genetic predisposition is combined with environmental factors. Despite the widely recognized developmental nature of the disease, symptoms do not emerge until late adolescence. Current therapeutic approaches are therefore employed too late, as brain alterations may have been present earlier than symptom onset. Here I review the developmental trajectory of the cortical circuits responsible for excitation-inhibition balance, which are at the center of current pathophysiological views, and propose that oxidative stress in cortical interneurons may be a final common pathway by which several different etiological factors can yield the cortical dysfunction characteristic of schizophrenia. If this scenario is correct, redox modulators may be beneficial for the disease. It is critical that the developmental trajectories of the factors yielding oxidative stress are taken into account for those approaches to succeed.
机译：精神分裂症是一种常见的疾病，其中强遗传易感性与环境因素结合在一起。尽管该病具有广泛的发育特性，但直到青春期晚期才出现症状。因此，目前的治疗方法为时已晚，因为脑部改变可能早于症状发作就出现了。在这里，我回顾了负责激发-抑制平衡的皮层回路的发展轨迹，这是当前病理生理学观点的中心，并提出皮层中间神经元的氧化应激可能是最终的常见途径，通过该途径，几种不同的病因可以产生精神分裂症的皮质功能障碍。如果这种情况是正确的，则氧化还原调节剂可能对该疾病有益。对于那些成功的方法，至关重要的是要考虑到产生氧化应激的因素的发展轨迹。

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