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首页> 外文期刊>The European Journal of Neuroscience >Exercise-induced stress resistance is independent of exercise controllability and the medial prefrontal cortex
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Exercise-induced stress resistance is independent of exercise controllability and the medial prefrontal cortex

机译：运动引起的压力抵抗力与运动可控制性和前额内侧皮层无关

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Exercise increases resistance against stress-related disorders such as anxiety and depression. Similarly, the perception of control is a powerful predictor of neurochemical and behavioral responses to stress, but whether the experience of choosing to exercise, and exerting control over that exercise, is a critical factor in producing exercise-induced stress resistance is unknown. The current studies investigated whether the protective effects of exercise against the anxiety- and depression-like consequences of stress are dependent on exercise controllability and a brain region implicated in the protective effects of controllable experiences, the medial prefrontal cortex. Adult male Fischer 344 rats remained sedentary, were forced to run on treadmills or motorised running wheels, or had voluntary access to wheels for 6 weeks. Three weeks after exercise onset, rats received sham surgery or excitotoxic lesions of the medial prefrontal cortex. Rats were exposed to home cage or uncontrollable tail shock treatment three weeks later. Shock-elicited fear conditioning and shuttle box escape testing occurred the next day. Both forced and voluntary wheel running, but not treadmill training, prevented the exaggerated fear conditioning and interference with escape learning produced by uncontrollable stress. Lesions of the medial prefrontal cortex failed to eliminate the protective effects of forced or voluntary wheel running. These data suggest that exercise controllability and the medial prefrontal cortex are not critical factors in conferring the protective effects of exercise against the affective consequences of stressor exposure, and imply that exercise perceived as forced may still benefit affect and mental health. Controllability of exercise was manipulated in rats using a novel forced wheel running paradigm closely resembling the pattern of voluntary exercise. Both voluntary and forced exercise prevented the behavioral effects of stress independently of the prefrontal cortex, a region sensitive to controllable experiences. These data suggest that exercise controllability is not a factor critical for conferring exercise-induced stress resistance, and that forced exercise may still benefit mental health. ? 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
机译：运动会增加对压力相关疾病（如焦虑和抑郁）的抵抗力。同样，控制感是神经化学和行为对压力反应的有力预测指标，但是未知的是，选择运动以及对该运动进行控制的经验是否是产生运动诱发的压力抗性的关键因素。目前的研究调查了运动对压力的焦虑和抑郁样后果的保护作用是否取决于运动的可控制性和涉及可控经验的保护作用的大脑区域，即前额叶内侧皮层。成年雄性Fischer 344大鼠仍久坐不动，被迫在跑步机或电动跑轮上行驶，或自愿进入车轮达6周。运动开始三周后，大鼠接受了假手术或内侧前额叶皮层的兴奋性毒性损伤。三周后，将大鼠暴露于家笼或无法控制的尾巴休克治疗。第二天进行了休克引起的恐惧心理调节和穿梭箱逃生测试。强制性和自愿性的车轮行驶，但不是跑步机的训练，都可以防止过度的恐惧条件和对无法控制的压力所产生的逃生学习的干扰。内侧前额叶皮层的病变未能消除强制或自愿轮转的保护作用。这些数据表明，运动控制性和内侧前额叶皮层不是赋予运动抵御应激源暴露影响的关键因素，并暗示被认为是强迫性运动仍可能有益于情感和心理健康。在大鼠中，运动的可控性使用了一种新型的，类似于自愿运动模式的强制车轮跑范例。自愿运动和强迫运动都可以防止压力的行为影响，而不受前额叶皮层（对可控经验敏感的区域）的影响。这些数据表明，运动可控制性不是赋予运动诱发的压力抗性的关键因素，而强迫运动仍可能有益于心理健康。 ？ 2012年欧洲神经科学学会联合会和布莱克韦尔出版有限公司。

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