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首页> 外文期刊>The European Journal of Neuroscience >The histaminergic system in human thalamus: correlation of innervation to receptor expression.
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The histaminergic system in human thalamus: correlation of innervation to receptor expression.

机译：人丘脑中的组胺能系统：神经支配与受体表达的关系。

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摘要

The mRNA expression of three histamine receptors (H1, H2 and H3) and H1 and H3 receptor binding were mapped and quantified in normal human thalamus by in situ hybridization and receptor binding autoradiography, respectively. Immunohistochemistry was applied to study the distribution of histaminergic fibres and terminals in the normal human thalamus. mRNAs for all three histamine receptors were detected mainly in the dorsal thalamus, but the expression intensities were different. Briefly, H1 and H3 receptor mRNAs were relatively enriched in the anterior, medial, and part of the lateral nuclei regions; whereas the expression level was much lower in the ventral and posterior parts of the thalamus, and the reticular nucleus. H2 receptor mRNA displayed in general very low expression intensity with slightly higher expression level in the anterior and lateropolar regions. H1 receptor binding was mainly detected in the mediodorsal, ventroposterolateral nuclei, and the pulvinar. H3 receptor binding was detected mainly in the dorsal thalamus, predominantly the periventricular, mediodorsal, and posterior regions. Very high or high histaminergic fibre densities were observed in the midline nuclear region and other nuclei next to the third ventricle, ventroposterior lateral nucleus and medial geniculate nucleus. In most of the core structures of the thalamus, the fibre density was very low or absent. The results suggest that histamine in human brain regulates tactile and proprioceptory thalamocortical functions through multiple receptors. Also, other, e.g. visual areas and those not making cortical connections expressed histamine receptors and contained histaminergic nerve fibres.
机译：分别通过原位杂交和受体结合放射自显影技术绘制并定量了正常人丘脑中三种组胺受体（H1，H2和H3）的mRNA表达以及H1和H3受体的结合。免疫组织化学技术用于研究正常人丘脑中组胺能纤维和末端的分布。主要在背丘脑中检测到所有三种组胺受体的mRNA，但表达强度不同。简而言之，H1和H3受体mRNA在前，中和部分外侧核区域相对富集。而在丘脑腹侧和后侧以及网状核中的表达水平要低得多。 H2受体mRNA通常显示非常低的表达强度，在前极和后极区域中表达水平略高。 H1受体结合主要在中枢，腹侧腹核和胸膜中检测到。 H3受体结合主要在丘脑背侧，主要是脑室周围，中枢和后部区域检测到。在中线核区域和邻近第三脑室，腹侧后外侧核和内侧膝状核的其他核中观察到非常高或很高的组胺能纤维密度。在丘脑的大多数核心结构中，纤维密度非常低或没有。结果表明，人脑中的组胺通过多种受体调节触觉和本体感受性丘脑皮质功能。另外，例如视觉区域和未建立皮层连接的区域表达组胺受体并含有组胺能神经纤维。

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