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首页> 外文期刊>The European Journal of Neuroscience >Maternal care influences neuronal survival in the hippocampus of the rat.
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Maternal care influences neuronal survival in the hippocampus of the rat.

机译：产妇保健会影响大鼠海马的神经元存活。

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Maternal care during the first week of postnatal life influences hippocampal development and function (Liu et al., 2000; Nature Neurosci., 3, 799-806). Offspring reared by mothers who exhibit increased levels of pup licking/grooming (LG) show increased hippocampal synaptic density and enhanced spatial learning and memory. Using 5-bromo-2'-deoxyuridine (BrdU), a thymidine analogue incorporated into cells during DNA synthesis, we examined the effects of early maternal care on hippocampal cell proliferation and neuronal survival in the rat. Twenty-four hours following injection on day 7 of life (P7) there were no differences in BrdU labelling in the offspring of high- compared with low-LG mothers, suggesting no maternal effect on the rate of proliferation at this age. However, 14 and 83 days following injection (P21 and P90), the offspring of high-LG mothers had significantly more surviving BrdU-labelled cells and BrdU-NeuN+-colabelled neurons in the dentate gyrus subgranular zone and granule cell layer. At P21, the offspring of high-LG mothers showed increased protein expression of basic fibroblast growth factor and significantly decreased levels of pyknosis. These findings suggest an influence of maternal care on neuronal survival in the hippocampus. Conversely, at the same time point there was a significantly higher level of hippocampal glial fibrillary acidic protein expression in the offspring of low-LG mothers. These findings emphasize the importance of early maternal care for hippocampal development.
机译：产后第一周的产妇护理会影响海马的发育和功能（Liu等人，2000; Nature Neurosci。，3，799-806）。由母亲饲养的后代表现出较高的舔舔/修饰（LG）水平，其海马突触密度增加，空间学习和记忆增强。使用5-溴-2'-脱氧尿苷（BrdU），一种在DNA合成过程中掺入细胞的胸苷类似物，我们检查了早期母体护理对大鼠海马细胞增殖和神经元存活的影响。在生命的第7天（P7）注射后二十四小时，高LG与低LG母亲的后代BrdU标记无差异，表明该年龄对孕产妇的增殖速率没有影响。但是，在注射后第14天和第83天（P21和P90），高LG水平母亲的后代在齿状回亚颗粒区和颗粒细胞层中存活的BrdU标记细胞和BrdU-NeuN +鳞状神经元的存活率明显更高。在P21时，高LG水平母亲的后代表现出碱性成纤维细胞生长因子的蛋白表达增加，而肌水平明显降低。这些发现表明孕产妇保健对海马神经元存活的影响。相反，在同一时间点，低LG母亲的后代海马神经胶质原纤维酸性蛋白表达水平明显升高。这些发现强调了早期母体护理对海马发育的重要性。

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