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首页> 外文期刊>The European Journal of Neuroscience >Decreased ethanol preference and wheel running in Nurr1-deficient mice.
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Decreased ethanol preference and wheel running in Nurr1-deficient mice.

机译：在Nurr1缺陷型小鼠中，乙醇偏好降低和滚轮运行降低。

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Nurr1 (Nr4a2) is a transcription factor expressed in dopamine cells from early development and throughout life. Null mutants for Nurr1 lack the ventral midbrain dopamine neurons and die soon after birth. Animals with a heterozygous deletion are viable and display no apparent abnormality. We have investigated the impact of heterozygous deletion of Nurr1 on ethanol consumption in adult mice as a model for drug-induced reward and on wheel running as a model for natural reward. Interestingly, Nurr1 heterozygous mice never developed high ethanol consumption nor did they develop as much running behaviour as did the wild-type animals. Thus, Nurr1 appears to have a key role for the reinforcing properties of ethanol and running that underlies the development of excessive reward-seeking behaviours characteristic for addiction. Quantitative trait loci mapping using C57Bl/6 and DBA/2 mice describe a locus for ethanol preference on chromosome 2, wherein Nurr1 is located. We found two dinucleotide repeats in the Nurr1 promoter that were longer in mice with low preference for ethanol (DBA/2 and 129/Sv) than in mice with high preference for ethanol (C57Bl/6J and C57Bl/6NIH). These sequential data are compatible with Nurr1 as a candidate gene responsible for the quantitative trait loci for ethanol preference on mouse chromosome 2. Together, our data thus imply involvement of Nurr1 in the transition to a state of high ethanol consumption as well as in the development of a high amount of wheel running in mice.
机译：Nurr1（Nr4a2）是多巴胺细胞从早期发育到终生表达的转录因子。 Nurr1的空突变体缺少腹侧中脑多巴胺神经元，出生后不久就死亡。具有杂合缺失的动物是有活力的，并且没有表现出明显的异常。我们已经调查了Nurr1杂合缺失对成年小鼠乙醇消耗的影响，作为药物诱导的奖励的模型，以及对车轮行驶作为自然奖励的模型的影响。有趣的是，Nurr1杂合小鼠从不消耗高乙醇，也没有像野生型动物那样产生大量的奔跑行为。因此，Nurr1似乎对乙醇和跑步的增强特性具有关键作用，这是成瘾特有的过度奖励寻求行为发展的基础。使用C57Bl / 6和DBA / 2小鼠的定量性状基因座图谱描述了Nurr1所在的2号染色体上乙醇偏好的位点。我们发现Nurr1启动子中的两个二核苷酸重复序列在对乙醇偏低的小鼠（DBA / 2和129 / Sv）中比对乙醇偏高的小鼠（C57Bl / 6J和C57Bl / 6NIH）更长。这些顺序数据与Nurr1相容，后者是负责小鼠染色体2上乙醇偏爱的定量性状基因座的候选基因。总之，我们的数据暗示Nurr1参与了向高乙醇消耗状态的转变以及开发过程。大量的轮子在老鼠身上奔跑。

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