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首页> 外文期刊>The European Journal of Neuroscience >Excitotoxic lesions of the prelimbic-infralimbic areas of the rodent prefrontal cortex disrupt motor preparatory processes.
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Excitotoxic lesions of the prelimbic-infralimbic areas of the rodent prefrontal cortex disrupt motor preparatory processes.

机译：啮齿动物前额叶皮层的前缘-下缘区域的兴奋毒性损害破坏了运动准备过程。

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The medial prefrontal cortex (mPFC) is involved in a variety of cognitive and emotional processes; in rodents its implication in motor planning is less known, however. We therefore investigated how the mPFC contributes to the information processes involved in the execution of a reaction time task in rats. Subjects were trained to rapidly release a lever at the onset of a cue light, which was presented after an unpredictable period of variable duration (500, 750, 1000 and 1250 ms). Excitotoxic lesions of the whole mPFC or two mPFC subregions [e.g. the dorsal anterior cingulate and the prelimbic-infralimbic (PL-IL) areas] were achieved by intracerebral infusions of ibotenic acid (9.4 micro g/ micro L) at different volumes. Extensive mPFC lesions produced increased premature responding and disrupted motor readiness, e.g. the distribution of preparatory patterns during the variable preparatory periods. The deficits lasted for 3 weeks and could be reinstated 2 months after the lesion by varying the durationof the preparatory periods to increase time uncertainty. Furthermore, lesions restricted to the PL-IL cortex areas reproduced all the deficits of mPFC lesions, whereas pregenual anterior cingulate cortex lesions had no effect. The results emphasize a critical role of the rat PL-IL region in motor preparatory processes. Hence, discrete lesions of this area reproduce some deficits such as impairment of time estimation and disinhibitory behaviours observed in humans with frontal hypoactivity.
机译：内侧前额叶皮层（mPFC）参与各种认知和情感过程;然而，在啮齿类动物中，其在运动计划中的含义尚不清楚。因此，我们研究了mPFC如何促进参与大鼠反应时间任务执行的信息过程。训练对象在提示灯开始时快速释放操纵杆，提示灯在一段不可预测的可变持续时间（500、750、1000和1250 ms）之后出现。整个mPFC或两个mPFC子区域的兴奋性毒性损害[例如，通过脑内输注不同体积的ibotenic acid（9.4 micro g / micro L）来达到背前扣带回和前缘-下缘（PL-IL）区域]。广泛的mPFC损伤会导致过早的反应增加，并破坏运动准备，例如可变准备期间的准备模式分布。缺陷持续了3周，可以通过改变预备期的持续时间以增加时间的不确定性，在病变后2个月内恢复。此外，限于PL-IL皮质区域的病变可再现mPFC病变的所有缺陷，而前扣带回皮质病变则无任何作用。结果强调了大鼠PL-IL区在运动准备过程中的关键作用。因此，该区域的离散病变会产生一些缺陷，例如在额叶活动不足的人中观察到的时间估计受损和抑制行为。

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