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首页> 外文期刊>The European Journal of Neuroscience >Modulation of olfactory learning in young rats through intrabulbar GABA(B) receptors.
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Modulation of olfactory learning in young rats through intrabulbar GABA(B) receptors.

机译：通过球内GABA（B）受体调节年轻大鼠的嗅觉学习。

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After training with an odour paired with foot shock on postnatal day 11, rat pups show an aversion to the odour in testing on postnatal day 12. The mechanisms underlying this aversive olfactory learning involve disinhibition of mitral/tufted cells in the olfactory bulb by the somatosensory stimulation-induced activation of centrifugal noradrenergic fibres originating in the locus coeruleus. The activity of mitral/tufted cells is regulated through gamma-aminobutyric acidA (GABA(A)) receptors in the external plexiform layer and GABA(B) receptors in the glomerular layer. We have previously presented that aversive olfactory learning in young rats is modulated through GABA(A) receptors in the olfactory bulb. In the present study we examined the consequence of manipulating GABA(B) receptors in the olfactory bulb during training. Baclofen, a GABA(B) receptor agonist when infused into the olfactory bulb during the pairing of an odour with foot shock, prevented aversive olfactory learning in a dose-dependent manner. Infusion of saclofen, a GABA(B) receptor antagonist, during training with a citral odour in the absence of foot shock produced aversive responses not only to the odour, but also to strange odours (benzaldehyde and vanillin) not previously presented. Such olfactory aversions were observed even if saclofen was infused without odour exposure. These results suggest that olfactory learning in young rats is modulated through GABA(B) receptors in the olfactory bulb.
机译：在出生后第11天接受气味训练并伴以脚震的训练后，大鼠幼崽在出生后第12天的测试中表现出对气味的厌恶。这种厌恶性嗅觉学习的潜在机制涉及通过体感作用抑制嗅球中的二尖瓣/簇状细胞。刺激诱导的源自点蓝藻的离心性去甲肾上腺素能纤维的激活。二尖瓣/簇状细胞的活性通过外部丛状层中的γ-氨基丁酸A（GABA（A））受体和肾小球层中的GABA（B）受体来调节。我们以前曾提出过，年轻大鼠的厌恶嗅觉学习是通过嗅球中的GABA（A）受体调节的。在本研究中，我们研究了在训练过程中操纵嗅球中GABA（B）受体的后果。 Baclofen是一种GABA（B）受体激动剂，在气味与脚震荡配对期间注入嗅球时，可以剂量依赖性的方式阻止厌恶性嗅觉学习。在没有脚震的情况下，在训练中添加柠檬酸沙氯芬（一种GABA（B）受体拮抗剂）会产生柠檬味，不仅产生对恶臭的厌恶反应，而且还会产生对以前未曾出现过的怪味（苯甲醛和香兰素）的厌恶反应。即使注入沙氯芬而没有气味暴露，也观察到这种嗅觉厌恶。这些结果表明，嗅觉学习是通过嗅球中的GABA（B）受体调节的。

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