Layer-specific immunocytochemical localization of GABA(B)R1a and GABA(B)R1b receptors in the rat piriform cortex.

Princivalle A; Spreafico R; Bowery N; De Curtis-M

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Layer-specific immunocytochemical localization of GABA(B)R1a and GABA(B)R1b receptors in the rat piriform cortex.

机译：大鼠梨状皮层中GABA（B）R1a和GABA（B）R1b受体的层特异性免疫细胞化学定位。

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摘要

A peculiar, layer-segregated immunoreactive distribution of GABABR1a and GABABR1b receptor antibodies is present in the piriform cortex of adult rats. The GABABR1a antibody selectively marked the neuropile in layer Ia, where afferent olfactory fibres and intrinsic GABAergic (gamma-aminobutyric acid) axons terminate on the distal apical dendrites of pyramidal neurons. The GABABR1b antibody was detected in the soma and the large basal dendrites of layer II and III neurons. The pattern of distribution observed supports the hypothesis that (presynaptic) GABABR1a receptors in the superficial molecular layer modulate neurotransmitter release in a feedforward synaptic circuit, whereas GABABR1b (postsynaptic) receptors mediate feedback inhibitory potentials on principal cells.

机译：成年大鼠的梨状皮层中存在GABABR1a和GABABR1b受体抗体的独特，分层隔离的免疫反应性分布。 GABABR1a抗体选择性标记Ia层中的神经桩，传入的嗅觉纤维和内在的GABAergic（γ-氨基丁酸）轴突终止于锥体神经元的远端顶突。在第II和III层神经元的体细胞和大型基底树突中检测到GABABR1b抗体。观察到的分布模式支持以下假说：表皮分子层中的（突触前）GABABR1a受体调节前馈突触回路中神经递质的释放，而GABABR1b（突触后）受体介导对主细胞的反馈抑制电位。

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来源
《The European Journal of Neuroscience》 |2000年第4期|共5页
作者
Princivalle A; Spreafico R; Bowery N; De Curtis-M;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Olfactory Pathways; Receptors; GABA-B; Antibodies; 嗅通路; 受体; GABA-B;

机译：Olfactory Pathways;Receptors;GABA-B;Antibodies;嗅通路;受体;GABA-B;

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1. Layer-specific immunocytochemical localization of GABA(B)R1a and GABA(B)R1b receptors in the rat piriform cortex. [J] . Princivalle A, Spreafico R, Bowery N, The European Journal of Neuroscience . 2000,第4期

机译：大鼠梨状皮层中GABA（B）R1a和GABA（B）R1b受体的层特异性免疫细胞化学定位。
2. Plasma membrane density of GABA_B-R1a, GABA_B-R1b, GABA-R2 and trimeric G-proteins in the course of postnatal development of rat brain cortex. [J] . K. Dlouhá, D. Kagan, L. Roubalová, Physiological Research . 2013,第5期

机译：大鼠大脑皮质出生后GABA _{B -R1a，GABA _{B -R1b，GABA-R2和三聚体G蛋白的质膜密度。}}
3. gamma-Aminobutyric acid (GABA) signaling components in Drosophila: immunocytochemical localization of GABA(B) receptors in relation to the GABA(A) receptor subunit RDL and a vesicular GABA transporter. [J] . Enell L, Hamasaka Y, Kolodziejczyk A, The Journal of Comparative Neurology . 2007,第1期

机译：果蝇中的γ-氨基丁酸（GABA）信号传导成分：GABA（B）受体相对于GABA（A）受体亚基RDL和水泡GABA转运蛋白的免疫细胞化学定位。
4. Localizing GABA receptors and glutamate transporters using conjugated quantum dots in rat cerebellum slices [C] . Abdel I. El Abed, Anne Baudot, Mireille Chat, MRS Meeting . 2010

机译：使用缀合的量子点在大鼠小脑切片中定位GABA受体和谷氨酸转运蛋白
5. Effects of whisker-trimming on GABAA receptors in S1 cortex. [D] . Salazar, Eduardo. 2004

机译：晶须修剪对S1皮质中GABAA受体的影响。
6. Repeated administration of desipramine and a GABAB receptor antagonist CGP 36742 discretely up-regulates GABAB receptor binding sites in rat frontal cortex. [O] . G. D. Pratt, N. G. Bowery 1993

机译：重复给予地昔帕明和GABA B受体拮抗剂CGP 36742可分别上调大鼠额叶皮质中GABA B受体的结合位点。
7. Repeated administration of desipramine and a GABAB receptor antagonist, CGP 36742, discretely up-regulates GABAB receptor binding sites in rat frontal cortex. [O] . Pratt, G. D., Bowery, N. G. 1993

机译：重复给予地昔帕明和GABA B受体拮抗剂CGP 36742，可分别上调大鼠额叶皮质中GABA B受体的结合位点。

Layer-specific immunocytochemical localization of GABA(B)R1a and GABA(B)R1b receptors in the rat piriform cortex.

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