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首页> 外文期刊>The European Journal of Neuroscience >Steroidogenic acute regulatory protein in the rat brain: cellular distribution, developmental regulation and overexpression after injury.
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Steroidogenic acute regulatory protein in the rat brain: cellular distribution, developmental regulation and overexpression after injury.

机译：大鼠脑中的类固醇急性调节蛋白：损伤后细胞分布，发育调节和过表达。

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摘要

The central nervous system synthesizes steroids which regulate the development and function of neurons and glia and have neuroprotective properties. The first step in this process involves the delivery of free cholesterol to the inner mitochondrial membrane where it can be converted into pregnenolone. This delivery is mediated by steroidogenic acute regulatory protein (StAR). Here, we present a detailed analysis of the distribution of StAR expression in neurons and glia, in the developing, adult and aged male rat brain. Immunohistochemical analysis revealed that StAR is widely distributed throughout the brain, although in each brain area it is restricted to very specific neuronal and astroglial populations. In most regions expressing StAR, immunoreactivity appeared at P10 and the levels of expression then either increased or remained constant until adulthood. In 2-year-old rat brains, StAR immunoreactivity was increased compared to young adults. StAR was expressed in the subventricular zone of the adult brain, in proliferating cells which incorporate BrdU as well as in germinal layers in the developing brain. These findings indicate that StAR expression is developmentally regulated and that StAR may play some function in regulating cell proliferation in the brain. Furthermore, StAR mRNA and protein levels were acutely and transiently increased in the hippocampus following excitotoxic brain injury induced by the administration of kainic acid. This raises the possibility that the up-regulation of StAR expression and the subsequent modifications in steroidogenesis may be part of the mechanisms used by the brain to cope with neurodegeneration.
机译：中枢神经系统合成的类固醇可调节神经元和神经胶质的发育和功能，并具有神经保护特性。此过程的第一步涉及将游离胆固醇传递至线粒体内膜，在此处可将其转化为孕烯醇酮。这种传递是由类固醇生成的急性调节蛋白（StAR）介导的。在这里，我们目前对发育中，成年和成年雄性大鼠大脑中神经元和神经胶质中StAR表达分布的详细分析。免疫组织化学分析显示，StAR在整个大脑中广泛分布，尽管在每个大脑区域中它仅限于非常特定的神经元和星形胶质细胞群。在大多数表达StAR的区域中，免疫反应性出现在P10处，然后表达水平升高或保持恒定直至成年。与年轻成年人相比，在2岁大的大鼠大脑中，StAR免疫反应性增加。 StAR在成年大脑的脑室下区域，掺入BrdU的增殖细胞以及发育中的脑的生发层中表达。这些发现表明，StAR的表达受到发育调节，并且StAR可能在调节脑细胞增殖中发挥某些作用。此外，在因施用海藻酸引起的兴奋性脑损伤后，海马中的StAR mRNA和蛋白水平急剧和短暂地增加。这增加了StAR表达的上调和类固醇生成的后续修饰可能是大脑用于应对神经退行性变的机制的一部分。

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