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首页> 外文期刊>The European Journal of Neuroscience >Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease.
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Hippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease.

机译：海马多巴胺D2受体与阿尔茨海默氏病的记忆功能相关。

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Post mortem studies have revealed a loss of dopamine D2 receptors in the temporal lobes in Alzheimer's disease (AD). Moreover, the role of hippocampal D2 receptors on memory performance has been suggested in experimental studies. However, there are no previous in vivo studies on extrastriatal D2 receptors in AD. Our aim was to examine in vivo whether hippocampal or temporal cortical dopamine D2 receptors are affected in AD and whether D2 receptor availability is associated with the memory dysfunction seen in AD. Fourteen patients with probable AD and 11 age- and sex-matched controls were studied with positron emission tomography using a dopamine D2/D3 receptor antagonist [(11)C]FLB 457. The D2 receptor binding potentials (BPs) were measured in extrastriatal brain regions and a neuropsychological investigation was performed on the patients with AD. In AD, the D2 receptor availability was reduced in the hippocampus: by 34% (P = 0.03) in the right hippocampus and by 14% (P = 0.78) in the left hippocampus as compared with controls. Multiple linear regression analysis showed that the BP in the right hippocampus had a significant positive association with verbal memory performance (Wechsler Memory Scale - Revised) (P = 0.001) and picture naming (the Boston Naming Test) (P = 0.002). Our findings suggest a role for temporal lobe D2 receptors in the memory and naming performance in AD, and suggest that studies to evaluate the efficiency of dopaminergic medication on patients with early AD might be warranted.
机译：验尸研究表明，阿尔茨海默氏病（AD）颞叶的多巴胺D2受体丢失。而且，在实验研究中已经提出了海马D2受体对记忆性能的作用。但是，目前尚无关于AD中纹状体外D2受体的体内研究。我们的目的是在体内检查海马或颞皮质多巴胺D2受体是否在AD中受到影响，以及D2受体的可利用性是否与AD中出现的记忆功能障碍有关。使用多巴胺D2 / D3受体拮抗剂[（11）C] FLB 457，对正电子发射断层扫描术对14名可能患有AD的患者和11名年龄和性别匹配的对照进行了研究。在纹状体外脑中测量了D2受体结合电位（BPs）区域，对AD患者进行了神经心理学调查。在AD中，与对照相比，海马中的D2受体利用率降低：右海马中降低了34％（P = 0.03），而左海马中降低了14％（P = 0.78）。多元线性回归分析表明，右海马的BP与言语记忆能力（韦氏记忆量表-修订版）（P = 0.001）和图片命名（波士顿命名测试）（P = 0.002）有显着正相关。我们的研究结果提示颞叶D2受体在AD的记忆和命名性能中发挥作用，并建议可能需要进行评估多巴胺能药物治疗AD早期疗效的研究。

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