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首页> 外文期刊>The European Journal of Neuroscience >Morphometrical analysis of dendritic arborization in axotomized retinal ganglion cells.
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Morphometrical analysis of dendritic arborization in axotomized retinal ganglion cells.

机译：轴突切除的视网膜神经节细胞中树突状乔化的形态计量学分析。

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It has been reported that section of the optic nerve in mammals causes death in >90% of the retinal ganglion cells (RGCs). The cells which survive the section experience an irreparable loss of many of their dendritic segments and a rapid retraction of the dendritic tree. However, some growth cones and abnormal processes have been also reported. Our aim was to make a quantitative study of the morphological changes found in rabbit RGCs after optic nerve section. The morphometrical analysis of the RGCs which survived the axotomy showed an increase in the diameter of the soma and a significant increase in the area of the dendritic field; also, the length of the dendritic segments was significantly longer in axotomized RGCs than in control cells. Terminal dendritic segments (T) and preterminal segments (PT) were both measured in control and axotomized cells; the length ratio of T : PT segments was significantly greater in the axotomized cells than in the controls. We conclude that RGCs which survived the axotomy experienced a significant growth of their terminal dendritic branches.
机译：据报道，哺乳动物的视神经切片在＞ 90％的视网膜神经节细胞（RGC）中引起死亡。在切片中存活的细胞经历了许多树突节段的不可挽回的损失，并且树突树迅速缩回。但是，也有一些生长锥和异常过程的报道。我们的目的是对视神经切片后兔RGC中发现的形态学变化进行定量研究。对在轴突切开术中幸存下来的RGC进行形态计量学分析，结果显示体直径增大，并且树突区域的面积显着增大。同样，在无切线的RGC中，树突节段的长度明显比对照细胞长。末梢树突节段（T）和末梢节段（PT）均在对照和被切开的细胞中测量;截肢细胞中，T：PT段的长度比明显大于对照。我们得出的结论是，在轴突切开术中幸存的RGC经历了其末端树突分支的显着增长。

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