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首页> 外文期刊>The European Journal of Neuroscience >Gene expression of neuropeptide Y in the nucleus of the solitary tract is activated in rats under restricted daily feeding but not under 48-h food deprivation.
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Gene expression of neuropeptide Y in the nucleus of the solitary tract is activated in rats under restricted daily feeding but not under 48-h food deprivation.

机译：在限制每日进食的情况下，大鼠的孤立道核中神经肽Y的基因表达被激活，但在缺食48小时后则未激活。

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摘要

The two neuropeptide Y (NPY) systems innervating the hypothalamic paraventrivular nucleus were examined regarding their roles in the prefeeding corticosterone peak developed under restricted daily feeding (RF). Protein and mRNA levels of NPY were measured in the arcuate nucleus (ARC) and the nucleus of the solitary tract (NST) in rats under 48-h food deprivation (48-hFD), RF, and 72-h food deprivation imposed after RF (post-RF 72-hFD) with 7 days of ad libitum feeding in between. NPY protein and mRNA levels in the ARC significantly increased with 48-hFD and decreased with re-feeding, whereas those in the NST were not changed by 48-hFD. When rats had RF imposed with free access to food from 10.00 to 12.00 h (lights on from 06.00 to 18.00 h) for 3 weeks, NPY concentrations in the ARC increased at 10.00 h, just prior to the daily meal, but those in the NST did not change significantly throughout the period examined. On the other hand, NPY mRNA levels in both the ARC and NST increased before the meal supply and remained high for 4 h after feeding. Under post-RF 72-hFD, the prefeeding peak of NPY mRNA was detected in the NST, but NPY mRNA levels in the ARC were continuously high throughout the 24-h period. These findings indicate that the NPY neurons from the NST are specifically activated by RF, whereas those from the ARC are generally stimulated by an increased food demand.
机译：检查了支配下丘脑室旁核的两个神经肽Y（NPY）系统，以了解它们在限制每日进食（RF）下发展的预饲皮质酮峰值中的作用。在48 h食物剥夺（RF）和RF后食物剥夺72 h的大鼠中，测量了弓状核（ARC）和孤立道核（NST）的NPY蛋白和mRNA水平（RF 72-hFD后），中间有7天的随意采食。 48-hFD时，ARC中的NPY蛋白和mRNA水平显着增加，而再次喂食时则降低，而NST中的NPY蛋白和mRNA水平在48-hFD中没有改变。当大鼠接受RF并在10.00到12.00 h（从06.00到18.00 h亮起）自由进食3周后，ARC的NPY浓度在每天进餐前的10.00 h升高，但是在NST中在整个检查期间没有明显变化。另一方面，在进食前，ARC和NST中的NPY mRNA水平均升高，并在进食后4 h保持较高水平。在RF 72-hFD后，在NST中检测到NPY mRNA的预饲高峰，但在整个24小时内，ARC中NPY mRNA的水平一直很高。这些发现表明，来自NST的NPY神经元被RF特异性激活，而来自ARC的NPY神经元通常受到食物需求增加的刺激。

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