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首页> 外文期刊>The European Journal of Neuroscience >Increase of morphine withdrawal in mice lacking A2a receptors and no changes in CB1/A2a double knockout mice.
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Increase of morphine withdrawal in mice lacking A2a receptors and no changes in CB1/A2a double knockout mice.

机译：缺乏A2a受体的小鼠中吗啡戒断的增加，而CB1 / A2a双敲除小鼠中的吗啡没有变化。

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摘要

CB1 cannabinoid and A2a adenosine receptors are highly expressed in the central nervous system where they modulate numerous physiological processes including emotional behaviour and the responses of several drugs of abuse. To investigate the contribution of these receptors in emotional-like responses and opioid dependence we have generated CB1/A2a double deficient mice (CB1-/-/A2a-/-). The spontaneous locomotor activity was reduced in double knockout as compared to wild-type animals. Emotional-like responses of CB1-/-/A2a-/- mice were investigated using the elevated plus-maze and the lit-dark box. Mutant mice exhibited an increased level of anxiety in both behavioural models. The specific involvement of CB1 and A2a receptors in morphine dependence was evaluated by using A2a knockout mice and CB1/A2a double mutant mice. The severity of naloxone-precipitated morphine withdrawal syndrome was significantly increased in the absence of A2a adenosine receptors whereas no modifications were observed in the double knockout mice. These results suggest that both receptors participate in the control of emotional behaviour and seem to play an opposite role in the expression of opioid physical dependence.
机译：CB1大麻素和A2a腺苷受体在中枢神经系统中高度表达，它们在其中调节许多生理过程，包括情绪行为和几种滥用药物的反应。为了研究这些受体在情绪样反应和阿片样物质依赖性中的作用，我们制备了CB1 / A2a双重缺陷小鼠（CB1-/-// A2a-/-）。与野生型动物相比，双重敲除的自发运动能力降低。使用高架迷宫和暗暗框研究了CB1-/-/ A2a-/-小鼠的类情感反应。在两种行为模型中，突变小鼠均表现出较高的焦虑水平。通过使用A2a基因敲除小鼠和CB1 / A2a双重突变小鼠评估了CB1和A2a受体对吗啡依赖性的特异性参与。在没有A2a腺苷受体的情况下，纳洛酮沉淀的吗啡戒断综合征的严重性显着增加，而在双基因敲除小鼠中未观察到任何改变。这些结果表明，两种受体都参与情绪行为的控制，并且在阿片样物质依赖中的表达似乎起相反的作用。

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