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首页> 外文期刊>The European Journal of Neuroscience >GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear.
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GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear.

机译：含有α5亚基的GABA受体在厌恶和食性条件以及条件性恐惧的消除中介导了痕量作用。

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Abstract A reduction in alpha5 subunit-containing gamma-aminobutyric acid (GABA)(A) receptors has been reported to enhance some forms of learning in mutant mouse models. This effect has been attributed to impaired alpha5 GABA(A) receptor-mediated inhibitory modulation in the hippocampus. The introduction of a point mutation (H105R) in the alpha5 subunit is associated with a specific reduction of alpha5 subunit-containing GABA(A) receptors in the hippocampus. The present study examined the modulation of associative learning and the extinction of conditioned response in these animals. The strength of classical conditioning can be weakened when a trace interval is interposed between the conditioned stimulus and unconditioned stimulus. Here we report that this 'trace effect' in classical conditioning was absent in the mutant mice - they were insensitive to the imposition of a 20-s trace interval. This effect of the mutation was most clearly in the female mice using an aversive conditioning paradigm, and inthe male mice using an appetitive conditioning paradigm. These gender-specific phenotypes were accompanied by a resistance to extinction of conditioned fear response in the mutant mice that was apparent in both genders. Our results identify neuronal inhibition in the hippocampus mediated via alpha5 GABA(A) receptors as a critical control element in the regulation of the acquisition and expression of associative memory.
机译：摘要据报道，减少含有α5亚基的γ-氨基丁酸（GABA）（A）受体可增强突变小鼠模型中的某些学习形式。该作用归因于海马中α5GABA（A）受体介导的抑制性调节受损。在alpha5亚基中引入点突变（H105R）与海马中含alpha5亚基的GABA（A）受体的特异性减少有关。本研究检查了这些动物中联想学习的调节和条件性反应的消失。当在条件刺激和非条件刺激之间插入微量间隔时，经典条件的强度会减弱。在这里，我们报道突变小鼠中不存在经典条件下的这种“痕迹效应”-它们对施加20秒的痕迹间隔不敏感。突变的影响在使用厌恶性条件范式的雌性小鼠中和使用开胃性条件范式的雄性小鼠中最为明显。这些性别特定的表型伴随着对突变小鼠中条件恐惧反应的消灭的抵抗，这在两种性别中都是明显的。我们的研究结果表明，通过α5GABA（A）受体介导的海马神经元抑制是关键的调控元件，调控相关记忆的获得和表达。

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