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首页> 外文期刊>The European Journal of Neuroscience >Group I metabotropic glutamate receptors regulate the frequency-response function of hippocampal CA1 synapses for the induction of LTP and LTD.
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Group I metabotropic glutamate receptors regulate the frequency-response function of hippocampal CA1 synapses for the induction of LTP and LTD.

机译：第一组代谢型谷氨酸受体调节海马CA1突触诱导LTP和LTD的频率响应功能。

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摘要

Synaptically released glutamate binds to ionotropic or metabotropic glutamate receptors. Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors and can be divided into three subclasses (Group I-III) depending on their pharmacology and coupling to signal transduction cascades. Group I mGluRs are coupled to phospholipase C and are implicated in several important physiological processes, including activity-dependent synaptic plasticity, but their exact role in synaptic plasticity remains unclear. Synaptic plasticity can manifest itself as an increase or decrease of synaptic efficacy, referred to as long-term potentiation (LTP) and long-term depression (LTD). The likelihood, degree and direction of the change in synaptic efficacy depends on the history of the synapse and is referred to as 'metaplasticity'. We provide direct experimental evidence for an involvement of group I mGluRs in metaplasticity in CA1 hippocampal synapses. Bath application of a low concentration of the specific group I agonist 3,5-dihydroxyphenylglycine (DHPG), which does not affect basal synaptic transmission, resulted in a leftward shift of the frequency-response function for the induction of LTD and LTP in naive synapses. DHPG resulted in the induction of LTP at frequencies which induced LTD in control slices. These alterations in the induction of LTD and LTP resemble the metaplastic changes observed in previously depressed synapses. In addition, in the presence of DHPG additional potentiation could be induced after LTP had apparently been saturated. These findings provide strong evidence for an involvement of group I mGluRs in the regulation of metaplasticity in the CA1 field of the hippocampus.
机译：突触释放的谷氨酸与离子型或代谢型谷氨酸受体结合。代谢型谷氨酸受体（mGluRs）是G蛋白偶联的受体，根据其药理学和信号转导级联反应的不同，可以分为三个亚类（I-III组）。 I组mGluRs与磷脂酶C偶联，并牵涉到几个重要的生理过程，包括活性依赖性突触可塑性，但它们在突触可塑性中的确切作用仍不清楚。突触可塑性可表现为突触功效的增加或降低，称为长期增强（LTP）和长期抑郁（LTD）。突触效力变化的可能性，程度和方向取决于突触的历史，被称为“可塑性”。我们提供I组mGluRs参与CA1海马突触的可塑性的直接实验证据。在浴中应用低浓度的特定I类激动剂3,5-二羟基苯基甘氨酸（DHPG）不会影响基础突触传递，导致在幼稚突触中诱导LTD和LTP的频率响应功能向左移动。 DHPG诱导LTP的频率在对照切片中诱导LTD。 LTD和LTP诱导的这些变化类似于先前抑制的突触中观察到的化生变化。此外，在DHPG存在的情况下，LTP明显饱和后，可以诱导其他增强作用。这些发现为I类mGluRs参与海马CA1区的代谢调控提供了有力的证据。

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