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首页> 外文期刊>The European Journal of Neuroscience >Long-lasting nicotinic modulation of GABAergic synaptic transmission in the rat nucleus accumbens associated with behavioural sensitization to amphetamine.
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Long-lasting nicotinic modulation of GABAergic synaptic transmission in the rat nucleus accumbens associated with behavioural sensitization to amphetamine.

机译：GABA能突触传递在大鼠伏隔核中的持久烟碱调节，与对苯丙胺的行为致敏有关。

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Abstract A robust increase in dopaminergic transmission in the nucleus accumbens (NAc) shell has been reported to be consistently associated with the long-term expression of behavioural sensitization to drugs of abuse. However, little is known about how this affects the neuronal network of the NAc. We made cellular recordings in NAc slices of saline- and amphetamine-pretreated adult rats and found that expression of behavioural sensitization was associated with long-lasting changes in the basal firing pattern of cholinergic interneurons up to 3 weeks after the last drug injection. Consequently, upon amphetamine sensitization, an inhibiting effect of the nicotinic receptor blocker mecamylamine on the amplitudes of spontaneous GABAergic synaptic currents as well as on the failure rate of electrically evoked GABAergic currents was found that was not present under control conditions. Thus, behavioural sensitization to amphetamine is associated with an up-regulation of the endogenous activation of nicotinicreceptors that, in turn, stimulate the GABAergic synaptic transmission within the NAc shell. This is a new mechanism by which drugs of abuse may induce alterations in the processing and integration of NAc inputs involved in psychomotor sensitization.
机译：摘要据报道伏伏核（NAc）壳中多巴胺能传递的强劲增加与对滥用药物的行为敏化的长期表达一致。然而，关于这如何影响NAc的神经网络知之甚少。我们在生理盐水和苯丙胺预处理的成年大鼠的NAc切片中进行了细胞记录，发现行为敏化的表达与胆碱能中间神经元的基础放电模式的持久变化有关，直到最后一次注射后3周。因此，在苯丙胺敏化后，发现烟碱样受体阻断剂美卡明胺对自发的GABA能突触电流的幅度以及对电诱发的GABA能电流的失效率的抑制作用在控制条件下是不存在的。因此，对苯丙胺的行为敏感性与烟碱受体的内源性激活的上调有关，而后者又会刺激NAc壳内的GABA能突触传递。这是一种新的机制，滥用药物可通过这种新机制诱导涉及精神运动敏化的NAc输入的加工和整合中的改变。

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