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首页> 外文期刊>The European Journal of Neuroscience >Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor.
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Learning and memory performance in mice lacking the GAL-R1 subtype of galanin receptor.

机译：在缺乏甘丙肽受体GAL-R1亚型的小鼠中的学习和记忆能力。

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Abstract The neuropeptide galanin induces performance deficits in a wide range of cognitive tasks in rodents. Three G-protein-coupled galanin receptor subtypes, designated GAL-R1, GAL-R2 and GAL-R3, have been cloned. The present study examined the role of GAL-R1 in cognition by testing mice with a null mutation in Galr1 on several different types of learning and memory tasks. Assessments of general health, neurological reflexes, sensory abilities and motor functions were conducted as control measures. Mutant mice were unimpaired in social transmission of food preference and the Morris water maze. In tests of fear conditioning, mutant mice were unimpaired in a delay version of cued fear conditioning. However, mice homozygous for the null mutation were impaired in a trace version of cued fear conditioning. Mutant mice were unimpaired in contextual fear conditioning, whether training was by the delay or trace protocol. General health, neurological reflexes, sensory abilities and motor functions did not differ across genotypes, indicating that the trace fear conditioning deficit was not an artifact of procedural disabilities. The findings of normal performance on several cognitive tasks and a selective deficit in trace cued fear conditioning in homozygous GAL-R1 mutant mice are discussed in terms of hypothesized roles of the GAL-R1 subtype. The generally normal phenotype of GAL-R1 null mutants supports the use of this line for identification of the receptor subtypes that mediate the cognitive deficits produced by exogenous galanin.
机译：摘要神经肽甘丙肽在啮齿类动物的多种认知任务中均会导致性能下降。已经克隆了三种G蛋白偶联的甘丙肽受体亚型，分别命名为GAL-R1，GAL-R2和GAL-R3。本研究通过测试在几种不同类型的学习和记忆任务中具有Galr1无效突变的小鼠，检验了GAL-R1在认知中的作用。评估总体健康状况，神经反射，感觉能力和运动功能，作为控制措施。突变小鼠在饮食偏好和莫里斯水迷宫的社会传播方面不受损害。在恐惧条件测试中，突变型小鼠在暗示性恐惧条件的延迟版本中未受损。但是，在暗示的恐惧条件的痕迹版本中，对无效突变纯合的小鼠受损。无论是通过延迟或跟踪方案进行训练，突变小鼠在情境恐惧条件下都不会受损。总体健康状况，神经反射，感觉能力和运动功能在不同基因型之间没有差异，这表明痕量恐惧调理缺陷不是程序障碍的产物。根据GAL-R1亚型的假设作用，讨论了纯合子GAL-R1突变小鼠在某些认知任务上的正常表现和微量提示恐惧条件的选择性缺陷。 GAL-R1无效突变体的一般正常表型支持使用该品系鉴定介导外源甘丙肽产生的认知缺陷的受体亚型。

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