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首页> 外文期刊>The European Journal of Neuroscience >Serotoninergic and noradrenergic axonal contacts associated with premotor interneurons in spinal pathways from group II muscle afferents.
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Serotoninergic and noradrenergic axonal contacts associated with premotor interneurons in spinal pathways from group II muscle afferents.

机译：II组肌肉传入神经的脊髓通路中与运动前神经元相关的5-羟色胺能和去甲肾上腺素能轴突接触。

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摘要

We investigated the possibility that monoaminergic axons make contacts with spinal interneurons which project to motor nuclei and are monosynaptically activated by group II muscle afferents. Interneurons in midlumbar spinal segments of adult cats were characterized electrophysiologically and intracellularly labelled with tetramethylrhodamine dextran. Serotoninergic and noradrenergic axons were identified with immunofluorescence in sections containing labelled cells. Contacts between monoaminergic axons and interneurons were investigated with three-colour confocal laser scanning microscopy and analysed with a computer reconstruction program. Cell bodies and dendritic trees of five cells were reconstructed and putative contacts were plotted. The average number of contacts formed by serotoninergic axons was 140 and the average number of noradrenergic contacts was 38. The majority (95%) of contacts were formed with dendrites; these were distributed over the entire dendritic tree, even on the most distal branches. These findings provide a morphological basis for the modulatory actions of monoamines on premotor spinal interneurons in pathways from group II muscle afferents.
机译：我们调查了单胺能轴突与脊髓中间神经元接触的可能性，该神经元突向运动核，并被II组肌肉传入神经突触激活。成年猫的腰椎中段脊髓中的神经元被电生理学和细胞内标记与四甲基罗丹明葡聚糖。在含有标记细胞的切片中通过免疫荧光鉴定了5-羟色胺能和去甲肾上腺素能轴突。用三色共聚焦激光扫描显微镜研究了单胺能神经轴突和中间神经元之间的接触，并用计算机重建程序进行了分析。重建了五个细胞的细胞体和树突树，并绘制了假定的接触点。由5-羟色胺能轴突形成的平均接触数为140，而无去甲肾上腺素能的接触的平均数为38。这些分布在整个树状树上，甚至分布在最远端的树枝上。这些发现为II组肌肉传入通路中单胺对运动前脊髓中神经元的调节作用提供了形态学基础。

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