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首页> 外文期刊>The European Journal of Neuroscience >Mu-opioid receptor knockout mice show diminished food-anticipatory activity.
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Mu-opioid receptor knockout mice show diminished food-anticipatory activity.

机译：Mu阿片受体基因敲除小鼠显示出减少食物预期的活动。

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Abstract We have previously suggested that during or prior to activation of anticipatory behaviour to a coming reward, micro -opioid receptors are activated. To test this hypothesis schedule induced food-anticipatory activity in micro -opioid receptor knockout mice was measured using running wheels. We hypothesized that micro -knockout mice show little food-anticipatory activity. In wildtype mice we observed that food-anticipatory activity increased proportional to reduced food intake levels during daily scheduled food access, and thus reflects the animal's physiological need for food. micro -Knockout mice do not adjust their schedule induced running wheel behaviour prior to and during feeding time in the same way as wildtype mice; rather than showing more running wheel activity before than during feeding, they showed an equal amount of activity before and during feeding. As food-anticipatory activity is dependent on the mesolimbic dopamine system and micro -opioid receptors regulate dopaminergic activity, these data suggest a change in the dopamine system's activity in micro -knockout mice. As we observed that micro -knockout mice tended to show a stronger locomotor activity response than wildtype mice to the indirect dopamine agonist d-amphetamine, it appears that the dopaminergic system per se is intact and sensitive to activation. We found no differences in the expression of pro-opiomelanocortin, a precursor of endogenous endorphin, in the arcuate nucleus between micro -knockout mice and wildtype mice during restricted feeding, showing that the micro -opioid receptor does not regulate endogenous endorphin levels. These data overall suggest a role for micro -opioid receptors in adapting reward related behaviour to the requirements of the environment.
机译：摘要我们之前曾提出，在预期行为激活或即将获得奖励之前或之前，微阿片受体被激活。为了检验该假设时间表，使用转轮测量了在微阿片受体敲除小鼠中诱导的食物预期活性。我们假设微敲除小鼠显示出很少的预期食物活动。在野生型小鼠中，我们观察到在预定的每日食物获取过程中，食物预期活性与食物摄入量减少成正比，从而反映出动物对食物的生理需要。 micro-Knockout小鼠在进食之前和进食期间不会像野生型小鼠一样调整其日程安排引起的跑轮行为;他们没有在进食之前和进食期间显示出更多的转轮活动，而是在进食之前和进食期间显示了相同数量的活动。由于食物预期活性取决于中脑边缘的多巴胺系统，而微阿片样物质受体调节多巴胺能活性，因此这些数据表明，微敲除小鼠中多巴胺系统的活性发生了变化。正如我们观察到的，微敲除小鼠对间接多巴胺激动剂d-苯异丙胺趋向于表现出比野生型小鼠更强的运动活性反应，看来多巴胺能系统本身是完整的，并且对激活敏感。我们发现微敲除小鼠和野生型小鼠在限制进食期间弓形核中内源性内啡肽前体的前opiomelanocortin的表达没有差异，表明微阿片受体并不调节内源性内啡肽水平。这些数据总体上暗示了微阿片受体在使奖励相关行为适应环境要求方面的作用。

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