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首页> 外文期刊>The European Journal of Neuroscience >Amygdala amino acid and monoamine levels in genetically Fast and Slow kindling rat strains during massed amygdala kindling: a microdialysis study.
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Amygdala amino acid and monoamine levels in genetically Fast and Slow kindling rat strains during massed amygdala kindling: a microdialysis study.

机译：遗传性快和慢点燃大鼠品系杏仁核点燃过程中杏仁核氨基酸和单胺水平：一项微透析研究。

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Abstract We investigated the neurochemistry of epileptic seizures in rats selectively bred to be seizure-prone (Fast) vs. seizure-resistant (Slow) to amygdala kindling. Microdialysis was used to measure levels of amino acids [glutamate, aspartate and gamma-aminobutyric acid (GABA)] and monoamines (noradrenaline, dopamine and serotonin) during 'massed' stimulation (MS) (every 6 min) of the ipsilateral amygdala for a total of 40 stimulation trials. Behavioral seizure profiles together with their afterdischarge thresholds (ADTs) and associated durations were assessed during the procedure, and subsequently were redetermined 1, 7 and 14 days later. Then normal 'daily' kindling commenced and continued until the animal reached the fully kindled state. During MS, several generalized seizures were triggered in Fast rats that were associated with long afterdischarge (AD) durations and intermittent periods of elevated thresholds, but in Slow rats, most stimulations were associated with stable ADTs and short ADs. Progressively increasing extracellular glutamate and decreasing GABA was observed in Fast rats during the MS, whereas Slow rats showed levels similar to baseline values. Levels of noradrenaline and dopamine, but not of serotonin, were also increased in both strains throughout the MS treatment. In Fast rats, a dramatic lengthening of AD durations occurred 7 and 14 days following MS, as well as subsequent strong positive transfer to daily kindling, all of which were not seen in Slow rats. Together, these results show that repeated, closely spaced stimulations of the amygdala can differentially alter excitatory and/or inhibitory transmitter levels in a seizure network, and that sensitivity to this manipulation is genetically determined.
机译：摘要我们研究了选择性诱发易发作（快）和耐癫痫（慢）的杏仁癫痫大鼠的癫痫性癫痫发作的神经化学。微透析用于测量同侧杏仁核的“批量”刺激（MS）（每6分钟）中氨基酸[谷氨酸，天冬氨酸和γ-氨基丁酸（GABA）]和单胺（去甲肾上腺素，多巴胺和5-羟色胺）的水平。总共40个刺激试验。在手术过程中评估行为性癫痫发作特征及其出院后阈值（ADT）和相关持续时间，随后在1、7和14天后重新确定。然后开始正常的“每日”点燃，并持续到动物达到完全点燃状态为止。在MS期间，快速大鼠触发了数次全身性癫痫发作，与持续放电时间长和阈值升高的间歇期有关，但在慢速大鼠中，大多数刺激与稳定的ADT和短暂的AD有关。在MS期间，快大鼠观察到逐渐增加的细胞外谷氨酸含量和GABA降低，而慢大鼠显示出与基线值相似的水平。在整个MS治疗中，两种菌株中的去甲肾上腺素和多巴胺的水平均升高，但5-羟色胺却未升高。在快速大鼠中，MS发生后7天和14天，AD持续时间显着延长，以及随后向每天点燃的强烈正向转移，而在慢速大鼠中都没有看到。总之，这些结果表明，对杏仁核的反复，近距离的刺激可以差异性地改变癫痫发作网络中的兴奋性和/或抑制性递质水平，并且遗传决定了对该操作的敏感性。

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