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首页> 外文期刊>The European Journal of Neuroscience >Turning behaviour induced by stimulation of the 5-HT receptors in the subthalamic nucleus.
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Turning behaviour induced by stimulation of the 5-HT receptors in the subthalamic nucleus.

机译：通过刺激丘脑下核中的5-HT受体诱导的转弯行为。

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The basal ganglia, which receive a rich serotonergic innervation, have been implicated in hyperkinetic and hypokinetic disorders. Moreover, a decrease in subthalamic nucleus (STN) activity has been associated with motor hyperactivity. To address the role of subthalamic serotonergic innervation in its motor function, turning behaviour was studied in rats with stimulation of the subthalamic serotonin (5-HT) receptors by intracerebral microinjections. The intrasubthalamic administration of 5-HT induced dose-dependent contralateral turning behaviour, with a maximal effect at a dose of 2.5 microg in 0.2 microL. Similar results were observed with microinjections of other 5-HT receptor agonists: quipazine (a 5-HT2B/C/3 agonist), MK-212 (a 5-HT2B/C agonist) and m-chlorophenylbiguanidine (a 5-HT3 agonist), while microinjections of 5-HT into the zona incerta or in the previously lesioned STN were ineffective. The effect of 5-HT was blocked by coadministration of the antagonist mianserin. Stimulation of subthalamic 5-HT receptors in animals bearing a lesion of the nigrostriatal pathway did not modify the motor response, which indicates that the dopamine innervation of the nucleus is not involved in this effect. Kainic acid lesion of the substantia nigra pars reticulata (SNr) suppressed the contralateral rotations elicited by stimulation of 5-HT2B/C/3 subthalamic receptors. This suggests a role of the subthalamic-nigral pathway in the turning activity. Furthermore, the partial blockade of glutamatergic receptors in the SNr by the antagonist DNQX increased the contralateral circling elicited by stimulation of 5-HT receptors in the STN. We concluded that the activation of the 5-HT2B/C and 5-HT3 subthalamic receptors elicited contralateral turning behaviour, probably via the subthalamic-nigral pathway.
机译：接受丰富的5-羟色胺神经支配的基底神经节与运动亢进和运动不足有关。此外，丘脑下核（STN）活性降低与运动亢进有关。为了解决丘脑下神经营养神经支配在其运动功能中的作用，研究了通过脑内显微注射刺激丘脑下5-羟色胺（5-HT）受体的大鼠的转弯行为。丘脑内注射5-HT诱导剂量依赖性对侧转弯行为，在0.2微升中以2.5微克的剂量作用最大。用微量注射其他5-HT受体激动剂观察到相似的结果：quipazine（5-HT2B / C / 3激动剂），MK-212（5-HT2B / C激动剂）和间氯苯基双胍（5-HT3激动剂） ，而将5-HT注射入不透明带或先前病变的STN中无效。拮抗剂米安色林共同给药可阻断5-HT的作用。刺激具有黑质纹状体途径损伤的动物的丘脑底5-HT受体刺激不会改变运动反应，这表明核的多巴胺神经支配不参与该作用。网状黑质（SNr）的海藻酸病变抑制了刺激5-HT2B / C / 3丘脑底受体引起的对侧旋转。这表明丘脑-黑质途径在转弯活动中的作用。此外，拮抗剂DNQX对SNr中的谷氨酸能受体的部分阻滞增加了STN中5-HT受体刺激引起的对侧旋光。我们得出的结论是，5-HT2B / C和5-HT3丘脑下受体的激活可能引起了对丘脑-黑质通路的对侧转向行为。

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