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首页> 外文期刊>The European Journal of Neuroscience >Nicotine reduces Abeta in the brain and cerebral vessels of APPsw mice.
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Nicotine reduces Abeta in the brain and cerebral vessels of APPsw mice.

机译：尼古丁会降低APPsw小鼠大脑和脑血管中的Abeta。

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摘要

Abstract Ten days treatment with nicotine reduced insoluble amyloid Abeta1-40 and Alphabeta1-42 peptides by 80% in the cortex of 9-month-old APPsw mice, which is more than that observed in 14.5-month-old mice following nicotine treatment for 5.5 months. A reduction in Abeta associated with cerebral vessels was observed in addition to that deposited as parenchymal plaques after 5.5 months treatment. The diminution in Abeta peptides observed was not accompanied by changes in brain alpha, beta or gamma secretase-like activities, NGF or BDNF protein expression measured in brain homogenates. A significant increase in sAPP was observed after nicotine treatment of SH-SY5Yneuroblastoma cells that could be blocked by the nicotinic antagonist mecamylamine. Attenuation of elevated [(125)I]-alphabungarotoxin binding (alpha7) in APPsw mice was observed after 5.5 months nicotine treatment. Both these observations suggest that the reduction in insoluble Abeta by nicotine might be in part mediated via the alpha7 nicotinic receptor. Further studies are required to identify potential mechanisms of the nicotine's amyloid-reducing effect.
机译：摘要尼古丁治疗10天后，在9个月大的APPsw小鼠的皮层中将不溶性淀粉样蛋白Abeta1-40和Alphabeta1-42肽减少了80％，这比在尼古丁治疗5.5个月后的14.5个月大的小鼠中观察到的要多。几个月。在5.5个月的治疗后，除了沉积为实质性斑块的沉积物外，还观察到与脑血管相关的Abeta含量降低。观察到的Abeta肽的减少并没有伴随大脑α，β或γ分泌酶样活性，脑匀浆中NGF或BDNF蛋白表达的变化。尼古丁处理SH-SY5Y母细胞瘤细胞后，sAPP显着增加，这可能被烟碱类拮抗剂美卡明胺所阻断。尼古丁治疗5.5个月后，在APPsw小鼠中观察到[[125）I]-α-真菌毒素结合（alpha7）升高。这两个发现都表明尼古丁对不溶性Abe​​ta的降低可能部分是通过alpha7烟碱受体介导的。需要进一步的研究来确定尼古丁的淀粉样蛋白减少作用的潜在机制。

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