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首页> 外文期刊>The European Journal of Neuroscience >Selective cholinergic denervation of the cingulate cortex impairs the acquisition and performance of a conditional visual discrimination in rats.
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Selective cholinergic denervation of the cingulate cortex impairs the acquisition and performance of a conditional visual discrimination in rats.

机译：扣带回皮层的选择性胆碱能去神经损害大鼠的条件性视觉辨别力的获得和表现。

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Results from excitotoxic lesion studies have implicated the cingulate cortex and its basal forebrain afferents in the acquisition and performance of conditional discrimination tasks. In the present work, we sought to clarify the role of specifically cholinergic projections from the vertical limb nucleus of the diagonal band (VDB) to the cingulate cortex in conditional visual discrimination (CVD) learning and performance in rats. We injected the cholinergic immunotoxin 192 IgG-saporin into the cingulate cortex to produce selective retrograde lesions of the cholinergic neurons projecting from the VDB to the cingulate cortex with the aim of sparing afferents of non-cingulate regions that can be disrupted by excitotoxic or immunotoxic VDB injections and non-cholinergic VDB projections that can also be damaged by excitotoxic lesions. Rats sustaining selective cholinergic denervation in this manner were significantly impaired relative to sham-operated animals in the acquisition and performance of a CVD rule of the type 'If lights are flashing FAST, press the left lever; if SLOW, press right'. Asymptotic performance of the lesion group was substantially lower than for control rats, indicating an enduring performance deficit. This impairment was associated with a selective disruption on trials with the FAST flashing stimulus. The results confirm the involvement of cholinergic innervation of the cingulate cortex in CVD performance; however, the nature of the deficit suggests a role for cholinergic modulation in task-relevant stimulus processing rather than stimulus-response learning per se.
机译：兴奋性毒性病变研究的结果表明扣带回皮层及其基底前脑传入体参与条件歧视任务的获取和执行。在本工作中，我们试图阐明从对角带（VDB）的垂直肢核到扣带状皮层的胆碱能投射在大鼠条件性视觉辨别（CVD）学习和行为中的作用。我们将胆碱能免疫毒素192 IgG-saporin注射入扣带状皮层中，以产生从VDB投射到扣带状皮层的胆碱能神经元的选择性逆行病变，目的是保留可被兴奋性或免疫毒性VDB破坏的非扣带性区域的传入注射和非胆碱能VDB投射也可能被兴奋性毒性损害所破坏。相对于假手术动物，以这种方式维持选择性胆碱能神经支配的大鼠在CVD规则的获取和执行中明显受损。如果慢，请按向右'。病变组的渐近表现明显低于对照大鼠，表明持续的表现缺陷。这种损害与在FAST闪烁刺激试验中的选择性干扰有关。结果证实了扣带回皮层的胆碱能神经支配参与了CVD的表现。然而，缺陷的性质表明胆碱能调节在与任务相关的刺激过程中的作用，而不是刺激-反应学习本身。

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