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首页> 外文期刊>The European Journal of Neuroscience >Long-term sensorineural hearing loss induces functional changes in the rat auditory nerve.
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Long-term sensorineural hearing loss induces functional changes in the rat auditory nerve.

机译：长期的感觉神经性听力损失会诱发大鼠听神经的功能改变。

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摘要

Loss of cochlear hair cells in the rat initiates degenerative change within the primary auditory neurons (ANs) of the cochlea. These degenerative changes include loss of peripheral processes, demyelination and ultimately cell death. This pathology will affect the biophysical processes involved in action potential generation and propagation to an electrical stimulus via a cochlear implant. We measured the response properties of ANs, with particular reference to their refractory behaviour, in normal, short- (9 weeks) and long-term (> 52 weeks) deafened rats. AN loss was moderate in the short-term and severe in the long-term deafened animals. AN activity was elicited using a brief electrical stimulus delivered via a bipolar electrode array implanted into the cochlea. The general response properties of ANs recorded from deafened cochleae were similar to those observed in normal cochleae, i.e. a monotonic increase in the probability of firing and a decrease in response latency and temporal jitter with increasing stimulus intensity. However, the absolute refractory period was significantly prolonged in animals deaf for > 12 months (P = 0.0026). Deafened animals also exhibited a highly significant increase in threshold compared with normal controls (P < 0.001). These functional changes have implications for recipients of cochlear implants and potential therapies directed toward halting or reversing AN pathology.
机译：大鼠耳蜗毛细胞的损失引发了耳蜗初级听觉神经元（AN）内的变性变化。这些退化性变化包括周围过程的丧失，脱髓鞘以及最终细胞死亡。这种病理学将影响与动作电位的产生有关的生物物理过程，并通过人工耳蜗传播到电刺激中。我们在正常，短期（9周）和长期（> 52周）失聪大鼠中测量了AN的响应特性，特别是参考其难治行为。在短期内，AN的损失是中等的，而在长期耳聋的动物中，AN的损失是严重的。使用短暂的电刺激引起的活动，该电刺激是通过植入耳蜗的双极电极阵列传递的。从耳聋的耳蜗中记录的AN的一般反应特性与正常耳蜗中观察到的相似，即随着刺激强度的增加，发射概率单调增加，响应潜伏期和时间抖动减少。但是，聋哑动物的绝对不应期显着延长了> 12个月（P = 0.0026）。与正常对照组相比，耳聋的动物的阈值也显着增加（P <0.001）。这些功能变化对人工耳蜗的接受者和针对停止或逆转AN病理的潜在疗法有影响。

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