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首页> 外文期刊>The European Journal of Neuroscience >Electrophysiological characterization of synaptic connections between layer VI cortical cells and neurons of the nucleus reticularis thalami in juvenile rats.
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Electrophysiological characterization of synaptic connections between layer VI cortical cells and neurons of the nucleus reticularis thalami in juvenile rats.

机译：幼年大鼠VI层皮层细胞与网状海藻核神经元之间突触连接的电生理特征。

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摘要

Corticothalamic (CT) feedback projections to the thalamus outnumber sensory inputs from the periphery by orders of magnitude. However, their functional role remains elusive. CT projections may directly excite thalamic relay cells or indirectly inhibit them via excitation of the nucleus reticularis thalami (nRT), a nuclear formation composed entirely of gamma-aminobutyric acidergic neurons. The relative strengths of these two pathways will ultimately control the effects of CT projections on the output of thalamic relay cells. However, corticoreticular synapses have not yet been fully physiologically characterized. Here, local stimulation of layer VI cells by focal application of K+ or AMPA elicited excitatory postsynaptic potentials in nRT neurons with a mean peak amplitude of 2.4 +/- 0.1 mV (n = 75, mean +/- SEM), a mean rise time (10-90%) of 0.74 +/- 0.03 ms and a weighted decay time constant of 11 +/- 0.3 ms. A pharmacological profile of responses was drawn in both current-clamp and voltage-clamp modes, showing the presence of a small N-methyl-d-aspartate receptor-dependent component at depolarized potentials. In two pairs of synaptically coupled layer VI cell-nRT neuron, moderate rates of transmission failures were observed while the latencies were above 5 ms in both cases. Our results indicate that the corticoreticular pathway fulfills the criteria for 'modulatory' inputs and is temporally restricted. We suggest that it may be involved in coincidence detection of convergent corticoreticular signals.
机译：丘脑的皮层丘脑（CT）反馈投影的数量要多于周围的感觉输入。但是，它们的功能作用仍然难以捉摸。 CT投射可能会直接激发丘脑中继细胞或通过激发网状丘脑（nRT）（一种完全由γ-氨基丁酸能神经元组成的核形成）间接抑制它们。这两种途径的相对强度最终将控制CT投射对丘脑中继细胞输出的影响。但是，皮质皮质突触尚未完全生理学表征。在这里，通过局部应用K +或AMPA局部刺激VI层细胞在nRT神经元中引起兴奋性突触后电位，其平均峰值幅度为2.4 +/- 0.1 mV（n = 75，平均值+/- SEM），平均上升时间（10-90％）为0.74 +/- 0.03毫秒，加权衰减时间常数为11 +/- 0.3毫秒。在电流钳位模式和电压钳位模式下均绘制了反应的药理图谱，表明在去极化电位下存在一个小的N-甲基-d-天冬氨酸受体依赖性成分。在两对突触耦合的第VI层VI细胞-nRT神经元中，在两种情况下均观察到中等程度的传输失败率，而延迟则高于5 ms。我们的结果表明，皮层通路满足“调节性”输入的标准，并且在时间上受到限制。我们建议它可能与收敛性皮质皮质信号的重合检测有关。

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