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首页> 外文期刊>The European Journal of Neuroscience >Attention to pain localization and unpleasantness discriminates the functions of the medial and lateral pain systems.
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Attention to pain localization and unpleasantness discriminates the functions of the medial and lateral pain systems.

机译：注意疼痛的局部性和不适感可以区分内侧和外侧疼痛系统的功能。

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Abstract Functional imaging studies have identified a matrix of structures in the brain that respond to noxious stimuli. Within this matrix, a division of function between sensory-discriminative and affective responses has so far been demonstrated by manipulating either pain intensity or unpleasantness under hypnosis in two different normal volunteer groups studied on separate occasions. Our study used positron emission tomography (PET) to demonstrate this division of function under more natural conditions in a healthy group of volunteers, using a CO(2) laser to provide nociceptive stimuli that selectively activate A-delta and C-fibres without contamination by touch sensations. We measured the differential cerebral responses to noxious and innocuous laser stimuli during conditions of selective attention to either the unpleasantness or location of the stimuli. Attention to location increased responses in the contralateral (right) primary somatosensory and inferior parietal cortices. This result implies that these components of the lateral pain system are concerned mainly with the localization of pain. In contrast, attention to unpleasantness increased responses in bilateral perigenual cingulate and orbitofrontal cortices, contralateral (right) amygdala, ipsilateral (left) hypothalamus, posterior insula, M1 and frontal pole. These areas comprise key components of the medial pain and neuroendocrine systems and the results suggest that they have a role in the affective response to pain. Our results indicate the importance of attentional effects on the pattern of nociceptive processing in the brain. They also provide the first clear demonstration, within a single experiment, of a major division of function within the neural pain matrix.
机译：摘要功能成像研究已经确定了大脑中对有害刺激作出反应的结构矩阵。在这个矩阵中，到目前为止，通过在两个分别研究的不同正常志愿者小组中，通过在催眠作用下操纵疼痛强度或不适来证明在感觉辨别和情感反应之间的功能划分。我们的研究使用正电子发射断层扫描（PET）来证明健康人群中在更自然条件下的这种功能划分，使用CO（2）激光提供伤害性刺激，选择性激活Aδ和C纤维而不受污染触感。我们在选择性注意刺激的不愉快或位置的条件下，测量了对有害和无害激光刺激的不同脑反应。注意位置会增加对侧（右侧）原代体感和顶下皮质的反应。该结果表明，侧痛系统的这些成分主要与疼痛的位置有关。相比之下，注意不愉快会增加双侧周缘扣带和眶额皮质，对侧（右侧）杏仁核，同侧（左侧）下丘脑，后岛，M1和额极的反应。这些区域包括内侧疼痛和神经内分泌系统的关键组成部分，结果表明它们在对疼痛的情感反应中具有作用。我们的结果表明注意效应对大脑伤害感受处理模式的重要性。它们还在单个实验中提供了神经痛矩阵内主要功能划分的第一个清晰证明。

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