...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Correlation between multiple climbing fibre regression and parallel fibre response development in the postnatal mouse cerebellum.
【24h】

Correlation between multiple climbing fibre regression and parallel fibre response development in the postnatal mouse cerebellum.

机译：产后小鼠小脑中多种攀援纤维消退与平行纤维反应发展之间的相关性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

At the neuromuscular junction elimination of supernumerary synaptic connections during development is owing to a competitive process between single neuronal populations, whereas in the central nervous system the interaction of different types of input could affect the process. In the cerebellum, the regression from multiple- to mono-innervation of the Purkinje cells by climbing fibres is virtually completed during the first two weeks of postnatal development. While it is clear that parallel fibres are important in the control of the regression, there are conflicting results in relation to whether an early phase of regression is independent of parallel fibre effects. We studied the precise timing of climbing fibre synapse development and decline and the relationship with the functional maturation of parallel fibres. Until postnatal day (P) 6 or 7, the synaptic currents generated by different climbing fibres become progressively more uniform in amplitude. However, between P7 and 14, the amplitudes of thecurrents increasingly diverge until only one fibre remains connected. These data are taken as evidence that, in multiply innervated Purkinje cells, competition between different climbing fibres appears at P7 and continues during the second postnatal week. Morphological and electrophysiological data demonstrate that parallel fibres synapses appear at P7 and their development is significantly correlated with the time course of the climbing fibre regression. These results provide no evidence for climbing fibre regression independent of parallel fibres before P7 and also suggest a dominant role of the parallel fibre input in the later phase.
机译：在神经肌肉连接处，发育过程中多余的突触连接的消除是由于单个神经元群体之间的竞争过程，而在中枢神经系统中，不同类型输入的相互作用可能会影响该过程。在小脑中，通过爬升纤维，浦肯野细胞从多神经支配到单神经支配的回归实际上在出生后的前两周内完成。虽然很明显平行纤维在回归控制中很重要，但是关于回归的早期阶段是否与平行纤维效应无关，结果存在矛盾。我们研究了攀爬纤维突触发展和下降的精确时机，以及与平行纤维功能成熟的关系。直到出生后第6天或第7天，由不同的攀爬纤维产生的突触电流的振幅逐渐变得更加均匀。但是，在P7和14之间，电流幅度逐渐发散，直到只有一根光纤保持连接。这些数据被用作证据，表明在多个神经支配的浦肯野细胞中，不同的攀爬纤维之间的竞争出现在P7处，并在产后第二周持续进行。形态学和电生理学数据表明，平行纤维突触出现在P7处，并且其发育与攀爬纤维消退的时间进程显着相关。这些结果没有提供证据表明攀爬纤维在P7之前独立于平行纤维而不会退化，并且也暗示了平行纤维输入在后期阶段的主导作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号