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首页> 外文期刊>The European Journal of Neuroscience >Corticostriatal functional interactions in Parkinson's disease: a rTMS/(11C)raclopride PET study.
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Corticostriatal functional interactions in Parkinson's disease: a rTMS/(11C)raclopride PET study.

机译：帕金森氏病的皮质口功能相互作用：rTMS /（11C）雷氯必利PET研究。

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Several animal studies have shown that striatal dopamine can be released under direct control of glutamatergic corticostriatal efferents. In Parkinson's disease (PD), abnormalities in corticostriatal interactions are believed to play an important role in the pathophysiology of the disease. Previously, we have reported that, in healthy subjects, repetitive transcranial magnetic stimulation (rTMS) of motor cortex (MC) induces focal dopamine release in the ipsilateral putamen. In the present study, using [11C]raclopride PET, we sought to investigate early PD patients with evidence of unilateral motor symptoms. We measured in the putamen changes in extracellular dopamine concentration following rTMS (intensity, 90% of the resting motor threshold; frequency, 10 Hz) of the left and right MC. The main objective was to identify potential differences in corticostriatal dopamine release between the hemisphere associated with clear contralateral motor symptoms (symptomatic hemisphere) and the presymptomatic stage of the other hemisphere (asymptomatic hemisphere). Repetitive TMS of MC caused a binding reduction in the ipsilateral putamen of both hemispheres. In the symptomatic hemisphere, while the amount of TMS-induced dopamine release was, as expected, smaller, the size of the significant cluster of change in [11C]raclopride binding was, instead, 61.4% greater than in the asymptomatic hemisphere. This finding of a spatially enlarged area of dopamine release, following cortical stimulation, may represent a possible in vivo expression of a loss of functional segregation of cortical information to the striatum and an indirect evidence of abnormal corticostriatal transmission in early PD. This has potential implications for models of basal ganglia function in PD.
机译：几项动物研究表明，纹状体多巴胺可以在谷氨酸能皮质皮质激素射出的直接控制下释放。在帕金森氏病（PD）中，皮层皮质相互作用的异常被认为在该疾病的病理生理学中起着重要作用。以前，我们已经报道过，在健康受试者中，运动皮层（MC）的重复经颅磁刺激（rTMS）诱导同侧壳状核中局灶性多巴胺释放。在本研究中，我们使用[11C] raclopride PET，试图调查早期PD患者有单方面运动症状的证据。我们测量了左右MC的rTMS（强度，静息运动阈值的90％;频率，10 Hz）后壳聚糖中胞外多巴胺浓度的变化。主要目的是确定与明确对侧运动症状相关的半球（有症状的半球）和另一半球的无症状前期（无症状的半球）之间的皮质口多巴胺释放的潜在差异。 MC的重复TMS导致两个半球同侧壳状核的结合减少。在有症状的半球中，尽管TMS诱导的多巴胺释放的量比预期的要少，但[11C]雷氯必利结合的显着变化簇的大小却比无症状的半球大61.4％。在皮质刺激后，发现多巴胺释放在空间上扩大了，这可能表示体内皮质信息向纹状体的功能隔离丧失的可能的体内表达，以及早期PD中皮质皮质通道传输异常的间接证据。这对PD的基底神经节功能模型具有潜在的影响。

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