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首页> 外文期刊>The European Journal of Neuroscience >Expression of A-type K channel alpha subunits Kv4.2 and Kv4.3 in rat spinal lamina II excitatory interneurons and colocalization with pain-modulating molecules.
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Expression of A-type K channel alpha subunits Kv4.2 and Kv4.3 in rat spinal lamina II excitatory interneurons and colocalization with pain-modulating molecules.

机译：A型K通道α亚基Kv4.2和Kv4.3在大鼠脊髓板层II兴奋性中神经元中的表达以及与疼痛调节分子的共定位。

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摘要

Voltage-gated K(+) channel alpha subunits Kv4.2 and Kv4.3 are the major contributors of somatodendritic A-type K(+) currents in many CNS neurons. A recent hypothesis suggests that Kv4 subunits may be involved in pain modulation in dorsal horn neurons. However, whether Kv4 subunits are expressed in dorsal horn neurons remains unknown. Using immunohistochemistry, we found that Kv4.2 and Kv4.3 immunoreactivity was concentrated in the superficial dorsal horn, mainly in lamina II. Both Kv4.2 and Kv4.3 appeared on many rostrocaudally orientated dendrites, whereas Kv4.3 could be also detected from certain neuronal somata. Kv4.3(+) neurons were a subset of excitatory inerneurons with calretinin(+)/calbindin(-)/PKCgamma(-) markers, and a fraction of them expressed micro-opioid receptors. Kv4.3(+) neurons also expressed ERK2 and mGluR5, which are molecules related to the induction of central sensitization, a mechanism mediating nociceptive plasticity. Together with the expression of Kv4.3 in VR1(+) DRG neurons, our data suggest that Kv4 subunits could be involved in pain modulation.
机译：电压门控K（+）通道α亚基Kv4.2和Kv4.3是许多CNS神经元中体树突状A型K（+）电流的主要贡献者。最近的假设表明，Kv4亚基可能参与背角神经元的疼痛调节。但是，是否在背角神经元中表达Kv4亚基仍是未知的。使用免疫组织化学，我们发现Kv4.2和Kv4.3免疫反应性集中在浅背角，主要在椎板II。 Kv4.2和Kv4.3都出现在许多旋转尾巴定向的树突上，而Kv4.3也可以从某些神经元的躯体中检测到。 Kv4.3（+）神经元是具有calretinin（+）/ calbindin（-）/ PKCgamma（-）标记的兴奋性神经元的子集，其中一部分表达微阿片受体。 Kv4.3（+）神经元还表达了ERK2和mGluR5，它们是与中枢敏化（一种介导伤害性可塑性的机制）的诱导有关的分子。连同VR1（+）DRG神经元中Kv4.3的表达，我们的数据表明Kv4亚基可能参与疼痛调节。

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