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首页> 外文期刊>The European Journal of Neuroscience >Differential modulation of anterior cingulate cortical activity by afferents from ventral tegmental area and mediodorsal thalamus.
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Differential modulation of anterior cingulate cortical activity by afferents from ventral tegmental area and mediodorsal thalamus.

机译：腹侧被盖区和腹中丘脑传入神经的前扣带回皮质活动的差异调节。

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Abstract A distinct increase in cell firing activity is reported in prefrontal cortex during working memory tasks. The afferents that modulate this activity are not yet identified. Using in vivo intracellular recording and labelling of prefrontal cortical pyramidal neurons in anaesthetized rats, we systematically evaluated the influences of afferent projections arising from the ventral tegmental area (VTA) and mediodorsal thalamus (MD) by phasic electrical stimulation with a range of stimulus frequencies. Both VTA- and MD-responsive pyramidal neurons exhibited extensive intracortical axon arborization. Neither single shocks to the VTA at 0.2 Hz, nor low frequency trains of stimuli at 1-4 Hz (< 5 Hz) interrupted the periodicity of membrane bistability in bistable pyramidal neurons. However, high-frequency VTA-train stimulation (10-50 Hz) interrupted the bistability, and produced sustained membrane depolarizations accompanied by intense tonic firing in a frequency-dependent manner. Electrical stimulationof MD (10-50 Hz) did not produce sustained activity in the same PFC neurons. Thus, the sustained activity induced by high-frequency VTA trains is input selective. This effect of VTA-train stimulation was attenuated by systemic injection of the D1 receptor antagonist, SCH 23390, and blocked by acute dopamine (DA) depletion produced via alpha-methyl-para-tyrosine pre-treatment, suggesting that sustained cortical activity is mediated by DA. Chemical stimulation of VTA via intra-VTA infusion of NMDA induced sustained activity similar to VTA-train stimulation. Thus, while both VTA- and MD-responsive pyramidal neurons exhibited extensive intracortical axon arborization, VTA synapses (as opposed to MD synapses) may be critically positioned in the dendritic arborizations of anterior cingulate cortical pyramidal neurons, which may allow their modulation of sustained activity in prefrontal bistable neurons.
机译：摘要在工作记忆任务期间，前额叶皮层的细胞放电活性明显增加。尚不清楚调节这一活动的传入。使用体内大鼠麻醉前大鼠皮质前额叶锥体神经元的细胞内记录和标记，我们系统地评估了在一定频率的刺激频率下，通过相电刺激对腹侧被盖区（VTA）和腹中丘脑（MD）产生的传入投影的影响。 VTA和MD响应的锥体神经元均表现出广泛的皮质内轴突乔木。既不会以0.2 Hz的频率对VTA进行单次电击，也不会以1-4 Hz（<5 Hz）的低频刺激来中断双稳态锥体神经元中膜双稳态的周期性。但是，高频VTA刺激（10-50 Hz）中断了双稳态，并产生了持续的膜去极化，并伴随着频率依赖性的强直性放电。 MD（10-50 Hz）的电刺激在相同的PFC神经元中未产生持续的活性。因此，由高频VTA列车引起的持续活动是选择性输入的。通过全身注射D1受体拮抗剂SCH 23390减弱了VTA火车刺激的这种作用，并被通过α-甲基-对-酪氨酸预处理产生的急性多巴胺（DA）消耗所阻断，表明持续的皮质活性被介导由DA。通过NMDA的VTA内输注对VTA的化学刺激可诱导类似于VTA火车刺激的持续活性。因此，虽然VTA和MD响应性锥体神经元均表现出广泛的皮层内轴突乔化，但VTA突触（与MD突触相反）可能位于前扣带回皮质锥体神经元的树突状树突中，这可能允许其调节持续活动在前额双稳态神经元中。

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