...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM).
【24h】

Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM).

机译：脊髓损伤诱导的排斥指导分子（RGM）的损伤表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The repulsive guidance molecule (RGM) is involved in the formation of the central nervous system (CNS) during development by modulating guidance of growing axons. However, a role of RGM in CNS injury remains to be established. We studied the expression of RGM in the spinal cord of rats with spinal cord injury (SCI). After SCI, RGM(+) cells accumulated in lesions and peri-lesional areas. During the first days after SCI, RGM expression was confined to neurons, ballooned neurite fibers/retraction bulbs, smooth muscle/endothelial cells, and to leucocytes infiltrating the lesion. Lesional RGM expression was frequently confined to hypertrophic beta-APP(+) and RhoA(+) neurites/retraction bulbs. With maturation of the lesion, we observed RGM expression by components of the developing scar tissue (cicatrix), such as fibroblastoid cells, reactive astrocytes and in addition a pronounced extracellular RGM deposition resembling neo-laminae. Frequent RGM(+), RhoA(+) coexpression by lesional retraction bulbs represent first preliminary evidence of RGM to exert growth inhibitory effects by the second messenger system RhoA. To date, RGM is one of the most potent axonal growth inhibitors identified and present in axonal growth impediments (i) oligodendrocytes; (ii) the plexus choroideus and (iii) components of the developing scar.
机译：排斥指导分子（RGM）在发育过程中通过调节生长轴突的指导参与中枢神经系统（CNS）的形成。然而，RGM在中枢神经系统损伤中的作用仍有待确定。我们研究了RGM在脊髓损伤（SCI）大鼠的脊髓中的表达。 SCI后，RGM（+）细胞积累在病变和病变周围区域。在SCI后的头几天，RGM的表达仅限于神经元，气球状神经突纤维/收缩球，平滑肌/内皮细胞以及浸润病变的白细胞。病变RGM表达经常限于肥大性β-APP（+）和RhoA（+）神经突/回缩球。随着病变的成熟，我们观察到RGM的表达是由发育中的瘢痕组织（瘢痕），成纤维细胞，反应性星形胶质细胞以及另外的类似于新板层的明显的RGM沉积组成。病变回缩球经常发生的RGM（+），RhoA（+）共表达代表RGM通过第二信使系统RhoA发挥生长抑制作用的第一个初步证据。迄今为止，RGM是已确定并存在于轴突生长障碍中的最有力的轴突生长抑制剂之一（i）少突胶质细胞; （ii）脉络丛和（iii）形成的疤痕。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号