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首页> 外文期刊>The European Journal of Neuroscience >Timed hypocaloric feeding and melatonin synchronize the suprachiasmatic clockwork in rats, but with opposite timing of behavioral output.
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Timed hypocaloric feeding and melatonin synchronize the suprachiasmatic clockwork in rats, but with opposite timing of behavioral output.

机译：定时低热量喂养和褪黑激素使大鼠超交叉精神钟同步，但行为输出的时机相反。

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摘要

Temporal organization of the molecular clockwork and behavioral output were investigated in nocturnal rats housed in constant darkness and synchronized to nonphotic cues (daily normocaloric or hypocaloric feeding and melatonin infusion) or light (light-dark cycle and daily 1-h light exposure). Clock gene (Per1, Per2 and Bmal1) and clock-controlled gene (Vasopressin) expression in the suprachiasmatic nuclei was assessed over 24 h. Light and exogenous melatonin synchronized the molecular clock, signaling, respectively, 'daytime' and 'nighttime', without affecting temporal organization of behavioral output (rest/activity rhythm). By contrast, synchronization to hypocaloric feeding led to a striking temporal change between gene expression in the suprachiasmatic clock and waveform of locomotor activity rhythm, rats then becoming active during the subjective day (diurnal-like temporal organization). When the time of feeding coincided with activity offset, normocaloric feeding also synchronized the locomotor activity rhythm with no apparent switch in temporal organization. Peak of Per2 expression in the piriform cortex occurred between the beginning and the middle of the activity/feeding period, depending on the synchronizer. These data demonstrate that even though the suprachiasmatic clockwork can be synchronized to nonphotic cues, hypocaloric feeding likely acts downstream from clock gene oscillations in the suprachiasmatic nuclei to yield a stable yet opposite organization of the rest/activity cycle.
机译：研究了夜生活在黑暗中的老鼠的分子发条的时间组织和行为输出，这些老鼠与非光信号（每天正常热量或低热量的喂养和褪黑激素输注）或光（光暗周期和每天1小时光照）同步。在24小时内评估了视交叉上核中的Clock基因（Per1，Per2和Bmal1）和时钟控制基因（Vasopressin）的表达。轻度褪黑激素和外源性褪黑激素使分子时钟同步，分别发出“白天”和“夜间”的信号，而不会影响行为输出（休息/活动节奏）的时间安排。相比之下，与低热量喂养的同步导致了上眼裂时钟中的基因表达与运动活动节律波形之间的显着时间变化，然后大鼠在主观一天中变得活跃（昼夜样时间组织）。当进食时间与活动偏移相吻合时，正常热量进食也使运动活动节律同步，而时间组织没有明显变化。梨状皮层中Per2表达的峰值出现在活动/进食期的开始和中间之间，具体取决于同步器。这些数据表明，即使视交叉上的发条可以与非光信号同步，低热量的进食很可能作用于跨交叉上核的时钟基因振荡的下游，从而产生一个稳定而相反的休息/活动周期组织。

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