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首页> 外文期刊>The European Journal of Neuroscience >Improved outcome of facial nerve repair in rats is associated with enhanced regenerative response of motoneurons and augmented neocortical plasticity.
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Improved outcome of facial nerve repair in rats is associated with enhanced regenerative response of motoneurons and augmented neocortical plasticity.

机译：大鼠面神经修复的结果改善与运动神经元的再生反应增强和新皮层可塑性增强有关。

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Within a recent study on the vibrissae motor performance after facial nerve repair in strains of blind (SD/RCS) and sighted (SD) rats we found that, despite persisting myotopic disorganization in the facial nucleus, the blind animals fully restored vibrissal whisking. Here we searched for morphological substrates of better recovery in the regenerating motoneurons and in the cerebral motor cortex. Expression analyses of the neurite growth-related proteins f-actin, neuronal class III beta-tubulin and plasticity-related gene-1, and stereological estimates of growth cone densities revealed a more vigorous regenerative response in the proximal nerve stump of blind SD/RCS rats compared with SD animals at 5-7 days after buccal nerve transection. Using c-Fos immunoreactivity as a marker for neuronal activation, we found that the volume of the cortex acutely responding to nerve transection (facial muscles reactive volume, FMRV) in both hemispheres of intact sighted rats was twofold smaller than that measured inblind animals. One month after transection and suture of the right facial nerve (FFA) we found a twofold increase in the FMRV in both rat strains compared with intact animals. The FMRV in SD/RCS animals, but not in SD rats, returned to the values in intact rats 2 months after FFA. Our findings suggest that enhanced plasticity in the CNS and an augmented regenerative response of the injured motoneurons contribute to better functional recovery in blind rats.
机译：在最近对盲（SD / RCS）和有视力（SD）大鼠的面部神经修复后触须运动功能的研究中，我们发现，尽管面部核中存在肌原位紊乱，盲人动物仍能完全恢复触须的拂动。在这里，我们在再生的运动神经元和大脑运动皮层中寻找更好恢复的形态学底物。神经突生长相关蛋白f-肌动蛋白，神经元III类β-微管蛋白和可塑性相关基因-1的表达分析以及生长锥密度的立体评估显示，盲SD / RCS的近端神经残端有更强烈的再生反应大鼠在颊神经横断后5-7天与SD动物进行比较。使用c-Fos免疫反应性作为神经元激活的标志物，我们发现在完好无损的视力大鼠的两个半球中，对神经横断急性反应的皮层体积（面部肌肉反应体积，FMRV）比盲人动物小两倍。在横断并缝合右面神经（FFA）一个月后，我们发现与完整动物相比，两种大鼠品系的FMRV均增加了两倍。在FFA后2个月，SD / RCS动物的FMRV恢复至完整大鼠的值，但SD大鼠未恢复。我们的研究结果表明，中枢神经系统的可塑性增强和受伤的运动神经元的再生反应增强，有助于失明大鼠更好的功能恢复。

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