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首页> 外文期刊>The European Journal of Neuroscience >dextro-Naloxone or levo-naloxone reverses the attenuation of morphine antinociception induced by lipopolysaccharide in the mouse spinal cord via a non-opioid mechanism.
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dextro-Naloxone or levo-naloxone reverses the attenuation of morphine antinociception induced by lipopolysaccharide in the mouse spinal cord via a non-opioid mechanism.

机译：右旋纳洛酮或左旋纳洛酮通过非阿片类药物机制逆转小鼠脊髓中脂多糖诱导的吗啡抗伤害感受的减弱。

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摘要

Glial stimulation by intrathecal injection of lipopolysaccharide (LPS) attenuated the tail-flick inhibition produced by morphine given intrathecally in the spinal cord of the male CD-1 mice. The phenomenon has been defined as antianalgesia. The effects of dextro-naloxone or levo-naloxone on the attenuation of morphine-produced tail-flick inhibition induced by LPS were then studied. Pretreatment with dextro-naloxone or levo-naloxone reversed the attenuation of the morphine-produced tail-flick inhibition induced by LPS. Pretreatment with dextro-naloxone or levo-naloxone alone did not affect the morphine-produced tail-flick inhibition. It is concluded that dextro-naloxone and levo-naloxone block the LPS-induced antianalgesia against morphine antinociception via a non-opioid mechanism.
机译：鞘内注射脂多糖（LPS）对神经胶质的刺激减弱了鞘内给予吗啡在雄性CD-1小鼠脊髓中产生的甩尾抑制作用。该现象已被定义为止痛药。然后研究了右旋纳洛酮或左旋纳洛酮对LPS诱导的吗啡产生的甩尾抑制作用的减弱作用。用右旋纳洛酮或左旋纳洛酮预处理可逆转LPS诱导的吗啡产生的甩尾抑制作用的减弱。单独使用右旋纳洛酮或左旋纳洛酮进行的预处理不会影响吗啡产生的甩尾抑制作用。结论是，右旋纳洛酮和左旋纳洛酮通过非阿片类药物机制阻断了LPS诱导的抗吗啡镇痛作用的抗痛觉过敏。

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