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首页> 外文期刊>The European Journal of Neuroscience >Extinction of auditory fear conditioning requires MAPK/ERK activation in the basolateral amygdala.
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Extinction of auditory fear conditioning requires MAPK/ERK activation in the basolateral amygdala.

机译：消除听觉恐惧条件需要在基底外侧杏仁核中激活MAPK / ERK。

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摘要

Whereas the neuronal substrates underlying the acquisition of auditory fear conditioning have been widely studied, the substrates and mechanisms mediating the acquisition of fear extinction remain largely elusive. Previous reports indicate that consolidation of fear extinction depends on the mitogen-activated protein kinase/extracellular-signal regulated kinase (MAPK/ERK) signalling pathway and on protein synthesis in the medial prefrontal cortex (mPFC). Based on experiments using the fear-potentiated startle paradigm suggesting a role for neuronal plasticity in the basolateral amygdala (BLA) during fear extinction, we directly addressed whether MAPK/ERK signalling in the basolateral amygdala is necessary for the acquisition of fear extinction using conditioned freezing as a read-out. First, we investigated the regional and temporal pattern of MAPK/ERK activation in the BLA following extinction learning in C57Bl/6J mice. Our results indicate that acquisition of extinction is associated with an increaseof phosphorylated MAPK/ERK in the BLA. Moreover, we found that inhibition of the MAPK/ERK signalling pathway by intrabasolateral amygdala infusion of the MEK inhibitor, U0126, completely blocks acquisition of extinction. Thus, our results indicate that the MAPK/ERK signalling pathway is required for extinction of auditory fear conditioning in the BLA, and support a role for neuronal plasticity in the BLA during the acquisition of fear extinction.
机译：尽管已经广泛研究了获得听觉恐惧条件的神经元基础，但是介导获得恐惧绝种的基础和机制仍然很难捉摸。先前的报道表明恐惧消退的巩固取决于有丝分裂原激活的蛋白激酶/细胞外信号调节激酶（MAPK / ERK）信号传导途径以及内侧前额叶皮层（mPFC）中的蛋白质合成。基于使用恐惧增强惊吓范式的实验表明恐惧消退过程中基底外侧杏仁核（BLA）中神经元可塑性的作用，我们直接解决了通过条件冷冻获得恐惧消退的基底外侧杏仁核中的MAPK / ERK信号是否必要作为读数。首先，我们研究了C57Bl / 6J小鼠的灭绝学习后BLA中MAPK / ERK激活的区域和时间模式。我们的结果表明，灭绝的获得与BLA中磷酸化MAPK / ERK的增加有关。此外，我们发现通过基底外侧杏仁核输注MEK抑制剂U0126对MAPK / ERK信号通路的抑制完全阻断了灭绝的获得。因此，我们的结果表明，MAPK / ERK信号通路对于BLA中的听觉恐惧条件的消退是必需的，并且在获得恐惧消退过程中支持BLA中神经元可塑性的作用。

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